{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T13:32:39Z","timestamp":1778765559825,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2003,3,20]],"date-time":"2003-03-20T00:00:00Z","timestamp":1048118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2003,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Zinc homeostasis in the brain is affected by dietary zinc deficiency, and its alteration may cause brain dysfunctions. On the basis of the previous evidence that hippocampal zinc was responsive to 12\u2010week zinc deprivation, responsiveness of hippocampal zinc to dietary zinc deficiency was examined in rats fed a zinc\u2010deficient diet for 4 weeks. Zinc concentration in the hippocampus was not decreased by zinc deprivation for 4 weeks. However, Timm's stain was extensively attenuated in the brain of the zinc\u2010deficient rats. In the brain of the zinc\u2010deficient rats, moreover, zinc concentration in the hippocampal extracellular fluid was approximately 30% of that of control rats. These results demonstrate that vesicular zinc is responsive to dietary zinc and may decrease easily under zinc deficiency. Zinc concentration in the hippocampal extracellular fluid during stimulation with high K<jats:sup>+<\/jats:sup> was significantly increased even in zinc\u2010deficient rats, although the increased levels of zinc were lower than the basal levels of zinc in control rats. The basal glutamate concentration in the hippocampal extracellular fluid was not significantly different between the control and zinc\u2010deficient rats. However, glutamate concentration in the hippocampal extracellular fluid during stimulation with high K<jats:sup>+<\/jats:sup> was more increased in the zinc\u2010deficient rats than in the control rats. Gamma aminobutyric acid (GABA) concentration in the hippocampal extracellular fluid during stimulation with high K<jats:sup>+<\/jats:sup> was increased in the control rats, but not in the zinc\u2010deficient rats. The present study suggests that the excitability of hippocampal glutamatergic neurons is enhanced by dietary zinc deficiency. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.10600","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T15:07:28Z","timestamp":1050419248000},"page":"537-542","source":"Crossref","is-referenced-by-count":89,"title":["Release of glutamate and GABA in the hippocampus under zinc deficiency"],"prefix":"10.1002","volume":"72","author":[{"given":"Atsushi","family":"Takeda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maki","family":"Hirate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruna","family":"Tamano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoto","family":"Oku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,3,20]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/308734a0"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00365.2001"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00592566"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7742(08)60279-2"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)61242-X"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.5.1471S"},{"key":"e_1_2_5_8_1","first-page":"169","article-title":"Growth, development and brain zinc levels in mice marginally or severely deprived of zinc during postembryonic brain development","volume":"3","author":"Golub MS","year":"1986","journal-title":"Nutr Behav"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/125.suppl_8.2263S"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(94)90152-X"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/308736a0"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(84)90166-3"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1992.tb10073.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-2396(200011)38:2<187::AID-SYN10>3.0.CO;2-R"},{"key":"e_1_2_5_15_1","first-page":"411","volume-title":"Trace substances environmental health","author":"O'Dell BL","year":"1976"},{"key":"e_1_2_5_16_1","volume-title":"The rat brain in stereotaxic coordinate","author":"Paxinos G","year":"1998"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1987.67.3.858"},{"key":"e_1_2_5_18_1","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1093\/jn\/104.11.1525","article-title":"Effect of zinc deficiency from day 18 of gestation and\/or during lactation on the development of some rat brain enzymes","volume":"104","author":"Prohaska JR","year":"1974","journal-title":"J Nutr"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.2.496S"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(94)90082-5"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-1281(82)80068-8"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(00)00044-8"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012982123386"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(19990801)57:3<405::AID-JNR13>3.0.CO;2-M"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02027-8"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4547(20010301)63:5<447::AID-JNR1040>3.0.CO;2-C"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1993.73.1.79"},{"key":"e_1_2_5_28_1","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1093\/jn\/113.10.1895","article-title":"Severe zinc deficiency:Effects on the distribution of nine elements (potassium, phosphorus, sodium, magnesium, calcium, iron, zinc, copper and manganese) in regions of the rat brain","volume":"113","author":"Wallwork JC","year":"1983","journal-title":"J Nutr"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/349521a0"}],"container-title":["Journal of Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjnr.10600","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.10600","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T07:29:04Z","timestamp":1697268544000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jnr.10600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,3,20]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2003,5,15]]}},"alternative-id":["10.1002\/jnr.10600"],"URL":"https:\/\/doi.org\/10.1002\/jnr.10600","archive":["Portico"],"relation":{},"ISSN":["0360-4012","1097-4547"],"issn-type":[{"value":"0360-4012","type":"print"},{"value":"1097-4547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,3,20]]}}}