{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:45:19Z","timestamp":1791189919451,"version":"4.1.0"},"reference-count":69,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2003,6,3]],"date-time":"2003-06-03T00:00:00Z","timestamp":1054598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2003,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human umbilical cord blood (hUCB) is a rich source of hematopoietic stem cells that have been used to reconstitute immune cells and blood lineages. Cells from another hematopoietic source, bone marrow, have been found to differentiate into neural cells and are effective in the treatment of stroke. In this study, we administered hUCB cells intravenously into the femoral vein or directly into the striatum and assessed which route of cell administration produced the greatest behavioral recovery in rats with permanent middle cerebral artery occlusion (MCAO). All animals were immunosuppressed with cyclosporine (CSA). When spontaneous activity was measured using the Digiscan automated system, it was found to be significantly less when hUCB was transplanted 24 hr after stroke compared with nontransplanted, stroked animals (<jats:italic>P<\/jats:italic> &lt; 0.01). Furthermore, behavioral recovery was similar with both striatal and femoral hUCB delivery. This is in contrast to the step test, in which significant improvements were found only after femoral delivery of the hUCB cells. In the passive avoidance test, transplanted animals learned the task faster than nontransplanted animals (<jats:italic>P<\/jats:italic> &lt; 0.05). Together, these results suggest that hUCB transplantation may be an effective treatment for brain injuries, such as stroke, or neurodegenerative disorders. In addition, intravenous delivery may be more effective than striatal delivery in producing long\u2010term functional benefits to the stroked animal. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.10659","type":"journal-article","created":{"date-parts":[[2003,7,14]],"date-time":"2003-07-14T10:09:00Z","timestamp":1058177340000},"page":"296-307","source":"Crossref","is-referenced-by-count":233,"title":["Intravenous versus intrastriatal cord blood administration in a rodent model of stroke"],"prefix":"10.1002","volume":"73","author":[{"given":"A.E.","family":"Willing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Lixian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Milliken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Poulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Zigova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Hart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Sanchez\u2010Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.R.","family":"Sanberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,6,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2002.17.4.668"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/nlme.1998.3865"},{"key":"e_1_2_6_4_1","first-page":"2630","article-title":"Neurological correlates of unilateral and bilateral \u201cstrokes\u201d of the middle cerebral artery in the rat","volume":"40","author":"Andersen CS","year":"1991","journal-title":"Physiol Behav"},{"key":"e_1_2_6_5_1","unstructured":"AndersenLB ShingoT WeissS.2002.Combined actions of epidermal growth factor (EGF) and erythropoietin (EPO) enhance neuronal migration from the subventricular zone (SVZ) into the lesioned adult striatum. In: Society for Neuroscience 2002 Abstract Viewer\/Itinerary Planner Program No. 524.8."},{"key":"e_1_2_6_6_1","unstructured":"AndjelkovicAV StamatovicSM KunkelSL KeepRF.2002.The potential role of MCP1 in the endothelial cell \u201copening\u201d role of RHO and RAC GTPases. In: Society for Neuroscience 2002 Abstract Viewer\/Itinerary Planner Program No. 580.5."},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-200106000-00014"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.17.6.1304"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V77.12.2591.2591"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3727\/096020197390022"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.283.5401.534"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(95)00103-P"},{"key":"e_1_2_6_13_1","first-page":"1","article-title":"The elevated body swing test (EBST): a measure of motor behavior asymmetry in animals with unilateral CNS lesions","volume":"10","author":"Borlongan CV","year":"1996","journal-title":"Neurosci Protoc"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199811160-00025"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1997.6730"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.290.5497.1775"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.115.10.2131"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(00)00006-X"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.4.1005"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/hs1101.098367"},{"key":"e_1_2_6_21_1","unstructured":"ChenY HallenbeckJM BolD ThomasK VogelSN.2002.Overexpression of MCP\u20101 in the brain exacerbates ischemic brain injury in mouse. In: Society for Neuroscience 2002 Abstract Viewer\/Itinerary Planner Program No. 389.2."},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.20-3-205"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2001.7835"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5356.1528"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1998.tb00641.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2002.7860"},{"key":"e_1_2_6_27_1","unstructured":"Garbuzova\u2010DavisSN WillingAE SaportaS DellisJT HaywoodAN JustenEB CahillDW SanbergPR.2002b.Intravenous and intraspinal transplantation of umbilical cord blood cells in a mouse model of familial amyotrophic lateral sclerosis. In: Society for Neuroscience 2002 Abstract Viewer\/Itinerary Planner Program No. 852.13."},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.26.4.627"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00295-4"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200111160-00030"},{"key":"e_1_2_6_31_1","unstructured":"HessDC HillWD CarrollJE FaganSC Martin\u2010StuddardA BrailerJ CarothersJ ZhengJ.2002.Ischemic induction of SDF\u20101 and CXCR4 associated with homing of bone marrow derived cells to infarct. In: Society for Neuroscience 2002 Abstract Viewer\/Itinerary Planner Program No. 389.3."},{"key":"e_1_2_6_32_1","first-page":"1460","article-title":"Pluripotent and lineage\u2010committed CD34+ subsets in leukapheresis products mobilized by G\u2010CSF, GM\u2010CSF versus a combination of both","volume":"24","author":"Ho AD","year":"1996","journal-title":"Exp Hematol"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.25.14482"},{"key":"e_1_2_6_34_1","unstructured":"JiangL CassadyCJ MalleryJ ZigovaT Sanchez\u2010RamosJ SongS SanbergPR WillingA.2002a.Does administration of umbilical cord blood stem cells alter the inflammatory response after stroke?In: Society for Neuroscience 2002 Abstract Viewer\/Itinerary Planner Program No. 852.13."},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature00870"},{"key":"e_1_2_6_36_1","unstructured":"KasselmanLJ RansohoffRM CaiN ZhangQJ MartinFJ KintnerJ WeiT MurphyAJ YancopoulosGD WiegandSJ.2002.Vascular endothelial growth factor (VEGF)\u2010mediated inflammation precedes angiogenesis in adult rat brain. In: Society for Neuroscience 2002 Abstract Viewer\/Itinerary Planner Program No. 868.14."},{"key":"e_1_2_6_37_1","first-page":"443","article-title":"Behavioral recovery following intravenous administration of human umbilical cord blood cells in rats with spinal cord injury","volume":"175","author":"Kim JJ","year":"2002","journal-title":"Exp Neurol"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(02)00823-7"},{"key":"e_1_2_6_39_1","first-page":"96","article-title":"Human umbilical cord cells (UCCs) distribute themselves throughout the degenerating human brain but do not transdifferentiate into neural cells","volume":"181","author":"Kosaras B","year":"2003","journal-title":"Exp Neurol"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200009000-00006"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.4.514"},{"key":"e_1_2_6_42_1","first-page":"97","article-title":"Early intracerebral and intra\u2010arterial transplantation of human umbilical cord blood cells into an ischemic rat brain model","volume":"181","author":"Lobel DA","year":"2003","journal-title":"Exp Neurol"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.3727\/096020198389924"},{"key":"e_1_2_6_44_1","unstructured":"MalhotraS SavitzI RosenbaumDM.2002.Erythropoietin (EPO)\/erythropoietin receptor (EPOR) underlie ischemic tolerance. In: Society for Neuroscience 2002 Abstract Viewer\/Itinerary Planner Program No. 98.8."},{"key":"e_1_2_6_45_1","unstructured":"MatsushitaH JohnstonMV LangeMS WilsonMA.2002.Protective effect of erythropoietin in neonatal hypoxic ischemia. In: Society for Neuroscience 2002 Abstract Viewer\/Itinerary Planner Program No. 697.10."},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199207000-00014"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.290.5497.1779"},{"key":"e_1_2_6_48_1","first-page":"1299","article-title":"[Quantitative characteristics of the state of the T\u2010 and B\u2010systems of immunity in the peripheral blood of patients with cerebrovascular disorders]","volume":"83","author":"Molchanov VV","year":"1983","journal-title":"Z Nevropatol Psikhiatrii Imeni S\u2010S Korsakova"},{"key":"e_1_2_6_49_1","unstructured":"NeebL RuscherK PrassK MuselmannC ScharffA FreyerD DirnaglU MeiselA.2002.Gene expression analysis of HIF\u20101 inducible genes in rat brain following ischemic preconditioning by desferrioxamine. In: Society for Neuroscience 2002 Abstract Viewer\/Itinerary Planner Program No. 97.10."},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.181177898"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(96)00240-2"},{"key":"e_1_2_6_52_1","unstructured":"SairanenTR Karjalainen\u2010LindsbergML PaetauA LindsbergPJ.2002.Erythropoietin and its receptor in human ischemic stroke. In: Society for Neuroscience 2002 Abstract Viewer\/Itinerary Planner Program No. 198.11."},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(87)90369-8"},{"key":"e_1_2_6_54_1","first-page":"283","article-title":"Mild brain ischemia increases cerebral lipid peroxidation and activates leukocytes in the peripheral blood of rats","volume":"12","author":"Sancesario G","year":"1997","journal-title":"Funct Neurol"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2000.7389"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2001.7748"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00610-1"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(94)90010-8"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)02431-2"},{"key":"e_1_2_6_60_1","first-page":"738","article-title":"Placental\/umbilical cord blood transplantation","volume":"84","author":"Sirchia G","year":"1999","journal-title":"Haematologica"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)02292-8"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(97)00338-8"},{"key":"e_1_2_6_63_1","first-page":"73","article-title":"Stroke induced lateralization of delayed\u2010type hypersensitivity in the early and chronic phase of the disease: a prospective study","volume":"46","author":"Tarkowski E","year":"1995","journal-title":"J Clin Lab Immunol"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)01128-2"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(99)00023-4"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1080\/00207450290025617"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4547(20000815)61:4<364::AID-JNR2>3.0.CO;2-C"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199908000-00006"},{"key":"e_1_2_6_69_1","first-page":"2291","article-title":"Human bone marrow stem cells exhibit neural phenotypes after transplantation and ameliorate neurological deficits with ischemic brain injury in rats","volume":"26","author":"Zhao L\u2010R","year":"2000","journal-title":"Soc Neurosci Abstr"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.3727\/096020198389915"}],"container-title":["Journal of Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjnr.10659","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.10659","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T01:55:27Z","timestamp":1697248527000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jnr.10659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,6,3]]},"references-count":69,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2003,8]]}},"alternative-id":["10.1002\/jnr.10659"],"URL":"https:\/\/doi.org\/10.1002\/jnr.10659","archive":["Portico"],"relation":{},"ISSN":["0360-4012","1097-4547"],"issn-type":[{"value":"0360-4012","type":"print"},{"value":"1097-4547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,6,3]]}}}