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We determine here the effect of FGF\u20102 on expression of the axonal growth\u2010associated phosphoprotein (GAP)\u201043 in retinal ganglion cells and tectum of <jats:italic>Rana pipiens<\/jats:italic> during regeneration of the optic nerve. In control retinas, GAP\u201043 protein was found in the optic fiber layer and in optic nerve; mRNA levels were low. After axotomy, mRNA levels increased sevenfold and GAP\u201043 protein was significantly increased. GAP\u201043 was localized in retinal axons and in a subset of RGC cell bodies and dendrites. This upregulation of GAP\u201043 was sustained through the period in which retinal axons reconnect with their target in the tectum. FGF\u20102 application to the injured nerve, but not to the eyeball, increased GAP\u201043 mRNA in the retina but decreased GAP\u201043 protein levels and decreased the number of immunopositive cell bodies. In the tectum, no treatment affected GAP\u201043 mRNA but FGF\u20102 application to the axotomized optic nerve increased GAP\u201043 protein in regenerating retinal projections. We conclude that FGF\u20102 upregulates the synthesis and alters the distribution of the axonal growth\u2010promoting protein GAP\u201043, suggesting that it may enhance axonal regrowth. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.10673","type":"journal-article","created":{"date-parts":[[2003,7,29]],"date-time":"2003-07-29T10:15:07Z","timestamp":1059473707000},"page":"507-517","source":"Crossref","is-referenced-by-count":17,"title":["FGF\u20102 modulates expression and distribution of GAP\u201043 in frog retinal ganglion cells after optic nerve injury"],"prefix":"10.1002","volume":"73","author":[{"given":"Ileana","family":"Soto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Marie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah 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