{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:16:22Z","timestamp":1791274582003,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,8,4]],"date-time":"2003-08-04T00:00:00Z","timestamp":1059955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2003,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this study, the suppressive effects of BmK IT2, a kind of Na<jats:sup>+<\/jats:sup> channel\u2010specific modulator from the venom of the scorpion <jats:italic>Buthus martensi<\/jats:italic> Karsch, on biphasic nociceptive behavior in rats and c\u2010Fos expression in rat spinal cord induced by formalin were investigated. Fifty microliters of 2.5% formalin were subcutaneously injected into the rat hind paw; 0.1 and 1 \u03bcg doses of BmK IT2 were subcutaneously administered into the rat ipsilateral hind paw 1 min before or 10 min after formalin injection individually, and the number of flinches per 5 min was counted. The detection of c\u2010Fos expression induced by formalin in either the absence or the presence of BmK IT2 was carried out with the ABC method. Biphasic nociceptive behavior in rats was significantly suppressed by pretreatment with BmK IT2. No. of flinches\/5 min in the second phase was also decreased by posttreatment with BmK IT2. In addition, c\u2010Fos expression induced by formalin was significantly inhibited in all laminae of L4\u20135 spinal cord by pre\u2010 or posttreatment with BmK IT2. The suppression of BmK IT2 in the first\u2010 and second\u2010phase behaviors may be attributed to the anesthesia of the toxin toward nociceptors and primary afferents and its selective modulation of tetrodotoxin\u2010resistant Na<jats:sup>+<\/jats:sup> currents of dorsal root ganglion neurons, respectively. In addition, the nonparallel suppression of BmK IT2 on flinch behavior and c\u2010Fos expression induced by formalin may be ascribed to the different activity patterns of afferent fibers and central neurons. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.10723","type":"journal-article","created":{"date-parts":[[2003,9,12]],"date-time":"2003-09-12T14:41:56Z","timestamp":1063377716000},"page":"167-173","source":"Crossref","is-referenced-by-count":26,"title":["Suppressive effects of BmK IT2 on nociceptive behavior and c\u2010Fos expression in spinal cord induced by 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