{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:33:56Z","timestamp":1792629236707,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,8,13]],"date-time":"2003-08-13T00:00:00Z","timestamp":1060732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Lundbeck Foundation"},{"name":"The Novo Nordic Foundation"},{"name":"The Ivan Nielsen Foundation"},{"name":"The Theodore and Vada Stanley Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2003,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Muscarinic cholinergic receptors of the M<jats:sub>5<\/jats:sub> subtype are expressed by dopamine\u2010containing neurons of the ventral tegmentum. These M<jats:sub>5<\/jats:sub> receptors modulate the activity of midbrain dopaminergic neurons, which play an important role in mediating reinforcing properties of abused psychostimulants like cocaine. The potential role of M<jats:sub>5<\/jats:sub> receptors in the reinforcing effects of cocaine was investigated using M<jats:sub>5<\/jats:sub> receptor\u2010deficient mice in a model of acute cocaine self\u2010administration. The M<jats:sub>5<\/jats:sub>\u2010deficient mice self\u2010administered cocaine at a significantly lower rate than wild\u2010type controls. In the conditioned place preference procedure, a classic test for evaluating the rewarding properties of drugs, M<jats:sub>5<\/jats:sub>\u2010deficient mice spent significantly less time in the cocaine\u2010paired compartment than control mice. Moreover, the severity of the cocaine withdrawal syndrome (withdrawal\u2010associated anxiety measured in the elevated plus\u2010maze) was significantly attenuated in mice lacking the M<jats:sub>5<\/jats:sub> receptor. These results demonstrate that M<jats:sub>5<\/jats:sub> receptors play an important role in mediating both cocaine\u2010associated reinforcement and withdrawal. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.10728","type":"journal-article","created":{"date-parts":[[2003,9,12]],"date-time":"2003-09-12T14:41:56Z","timestamp":1063377716000},"page":"91-96","source":"Crossref","is-referenced-by-count":113,"title":["Role for M<sub>5<\/sub> muscarinic acetylcholine receptors in cocaine addiction"],"prefix":"10.1002","volume":"74","author":[{"given":"Anders","family":"Fink\u2010Jensen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Fedorova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gitta","family":"W\u00f6rtwein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P. D.","family":"Woldbye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Th\u00f8ger","family":"Rasmussen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgane","family":"Thomsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom G.","family":"Bolwig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen M.","family":"Knitowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"McKinzie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahisa","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Wess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Basile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,8,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.162371899"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.09-10-03400.1989"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-02-00714.1996"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(91)90343-M"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(88)90190-0"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(89)90012-2"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(89)90033-6"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(89)90450-4"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2000.00250.x"},{"key":"e_1_2_6_11_1","first-page":"1","article-title":"M5 muscarinic receptors are required for prolonged accumbal dopamine release after electrical stimulation of the pons in mice","volume":"21","author":"Forster GL","year":"2002","journal-title":"J Neurosci"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2011738"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.18.10483"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050038"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)90422-8"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.9.3.482"},{"key":"e_1_2_6_17_1","first-page":"395","article-title":"Muscarine depolarizes rat substantia nigra zona compacta and ventral tegmental neurons in vitro through M1\u2010like receptors","volume":"253","author":"Lacey MG","year":"1990","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-09-05859.1995"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(93)90072-N"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(98)00003-3"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/262305a0"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)00043-P"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(98)00060-4"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(90)90064-G"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.18.7050"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.251542998"},{"key":"e_1_2_6_27_1","first-page":"149","article-title":"Development of antisera selective for m4 and m5 muscarinic cholinergic receptors: distribution of m4 and m5 receptors in rat brain","volume":"43","author":"Yasuda RP","year":"1993","journal-title":"Mol Pharmacol"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-23-08861.2000"}],"container-title":["Journal of Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjnr.10728","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.10728","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T11:26:17Z","timestamp":1700220377000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jnr.10728"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,8,13]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,10]]}},"alternative-id":["10.1002\/jnr.10728"],"URL":"https:\/\/doi.org\/10.1002\/jnr.10728","archive":["Portico"],"relation":{},"ISSN":["0360-4012","1097-4547"],"issn-type":[{"value":"0360-4012","type":"print"},{"value":"1097-4547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,8,13]]}}}