{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:18:32Z","timestamp":1791109112166,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,8,20]],"date-time":"2003-08-20T00:00:00Z","timestamp":1061337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2003,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>One pathological characteristic of Alzheimer's disease (AD) is extensive synapse loss. Presenilin 1 (PS1) is linked to the pathogenesis of early onset familial Alzheimer's disease (FAD) and is localized at the synapse, where it binds N\u2010cadherin and modulates its adhesive activity. To elucidate the role of the PS1\/N\u2010cadherin interaction in synaptic contact, we established SH\u2010SY5Y cells stably expressing wild\u2010type (wt) PS1 and dominant\u2010negative (D385A) PS1. We show that the formation of cadherin\u2010based cell\u2013cell contact among SH\u2010SY5Y cells stably expressing D385A PS1 was suppressed. Conversely, wt PS1 cells exhibited enhanced cell\u2013cell contact and colony formation. Suppression of cell\u2013cell contact in D385A cells was accompanied by an alteration in N\u2010cadherin subcellular localization; N\u2010cadherin was retained mainly in the endoplasmic reticulum (ER) and cell surface expression was reduced. We conclude that PS1 is essential for efficient trafficking of N\u2010cadherin from the ER to the plasma membrane. PS1\u2010mediated delivery of N\u2010cadherin to the plasma membrane is important for N\u2010cadherin to exert its physiological function, and it may control the state of cell\u2013cell contact. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.10753","type":"journal-article","created":{"date-parts":[[2004,2,20]],"date-time":"2004-02-20T15:01:20Z","timestamp":1077289280000},"page":"184-191","source":"Crossref","is-referenced-by-count":40,"title":["Presenilin 1 is involved in maturation and trafficking of N\u2010cadherin to the plasma 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