{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T05:06:49Z","timestamp":1773983209246,"version":"3.50.1"},"reference-count":66,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2003,10,17]],"date-time":"2003-10-17T00:00:00Z","timestamp":1066348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The object of this study was to determine if chronic exposure to mild concentrations of CO in air caused changes in the integrity of the inferior colliculus during the most active period of synaptogenesis\/auditory development. We examined all subregions of the inferior colliculus (IC) of rats by immunocytochemical approaches after pups were exposed chronically to CO concentrations of, 0, 12.5, 25, and 50 ppm in air starting at Day 8 through 20\u201322 days of age. Mother\u2010reared pups were compared to the gastrostomy\u2010reared pups with or without CO exposure for basal neural activity, using c\u2010Fos immunoreactivity as a marker. Half the rats were examined at 27 days of age, 5 days after the end of CO exposure, and the other half were examined 50 days later at 75\u201377 days of age. In the central nucleus of the IC, the number of cells expressing a basal level of c\u2010Fos was decreased significantly in the CO\u2010exposed animals when compared to controls; however, there was little or no difference in the number of cells expressing c\u2010Fos in the other subregions of the IC. We conclude that the central nucleus of the inferior colliculus is affected selectively by mild CO exposure (0.0012% in air) and that this reduction in neuronal activity persists into adulthood. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.10809","type":"journal-article","created":{"date-parts":[[2003,11,18]],"date-time":"2003-11-18T21:24:19Z","timestamp":1069190659000},"page":"655-665","source":"Crossref","is-referenced-by-count":18,"title":["Mild carbon monoxide exposure impairs the developing auditory system of the rat"],"prefix":"10.1002","volume":"74","author":[{"given":"Douglas S.","family":"Webber","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rose A.","family":"Korsak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren K.","family":"Sininger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon L.","family":"Sampogna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Edmond","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,10,17]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"ACGIH2002.TVLs and BEIs based on the documentation of the threshold limits for chemical substances and physical agents and biological exposure indices. Cincinnati: American Conf of Gov Industrial Hygen. p20."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-195-43152"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19890139"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59989670166-3"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.298.6676.795"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1385-299X(98)00003-8"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1990.68.2.604"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(96)00185-2"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)01840-5"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(99)00044-1"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(99)00157-4"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(84)90005-1"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj1060029"},{"key":"e_1_2_6_15_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4471-1766-7","volume-title":"Brain, behavior, and iron in the infant diet","author":"Dobbing J","year":"1990"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/121.9.1323"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)90819-H"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(89)90106-8"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/58.2.315"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1996.8027"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(87)90024-4"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(88)90049-4"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(99)70324-0"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-4328(94)00147-8"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1198116"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(00)00451-2"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)00034-6"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(97)01024-3"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0668.1999.t01-1-00004.x"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.973133"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10813"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903330102"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02536115"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114436"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/98.4.404"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902220206"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200201001-00002"},{"key":"e_1_2_6_38_1","first-page":"314","article-title":"The laminar structure of the inferior colliculus of the cat","volume":"148","author":"Morest DK","year":"1964","journal-title":"Anat Rec"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19880120"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902220207"},{"key":"e_1_2_6_41_1","unstructured":"OSHA Salt Lake Technical Center Inorganic Methods Evaluation Branch:http:\/\/beta.osha\u2010slc.gov\/dts\/sltc\/methods\/inorganic\/id210\/id210.html. Accessed February2003."},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.2000.279.6.L1029"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/20.2.405"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(99)00217-6"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01611726"},{"key":"e_1_2_6_46_1","first-page":"283","article-title":"Carbon monoxide and the embryo","volume":"41","author":"Robkin MA","year":"1997","journal-title":"Int J Dev Biol"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901470103"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901490303"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(92)90706-D"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19990208)404:2<258::AID-CNE9>3.0.CO;2-U"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(92)90617-G"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489309126171"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(97)00103-8"},{"key":"e_1_2_6_54_1","first-page":"205","article-title":"Metabolic mapping with cellular resolution: c\u2010fos vs. 2\u2010deoxyglucose","volume":"7","author":"Sharp FR","year":"1993","journal-title":"Crit Rev Neurobiol"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(92)90623-J"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420300212"},{"key":"e_1_2_6_57_1","first-page":"109","article-title":"Critical periods in brain development","volume":"156","author":"Smart JL","year":"1991","journal-title":"Ciba Found Symp"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(97)00032-5"},{"key":"e_1_2_6_59_1","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1093\/jn\/112.8.1506","article-title":"Metabolism in the artificially reared rat pup: effect of an atypical rat milk substitute","volume":"112","author":"Sonnenberg N","year":"1982","journal-title":"J Nutr"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10808"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1998.8553"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/59.3.218"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145701002450"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-0102(94)90141-4"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1033.2002.02987.x"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)00633-G"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1995.tb01157.x"}],"container-title":["Journal of Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjnr.10809","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.10809","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T18:21:35Z","timestamp":1700245295000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jnr.10809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,10,17]]},"references-count":66,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2003,12]]}},"alternative-id":["10.1002\/jnr.10809"],"URL":"https:\/\/doi.org\/10.1002\/jnr.10809","archive":["Portico"],"relation":{},"ISSN":["0360-4012","1097-4547"],"issn-type":[{"value":"0360-4012","type":"print"},{"value":"1097-4547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,10,17]]}}}