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Compared with the case in normal individuals, the T and B lymphocytes in AD patients and murine models are hyporesponsive to A\u03b2. However, depending on the route of delivery, tolerance can be overcome by vaccination, with the induction of an anti\u2010A\u03b2\u2010mediated immune response. Through mechanisms that are incompletely understood, immunized APP transgenic animals show markedly reduced A\u03b2 deposition, preservation of normal neuronal architecture, and improved performance in memory and spatial learning tasks. In human trials, A\u03b2 vaccination stabilized cognition and slowed the progression of dementia. Neuropathologic examination of a vaccinated subject showed reduced cortical A\u03b2 without changes in other AD\u2010associated pathology. However, in some patients, vaccination induced severe meningoencephalitis, causing the trial to be terminated. Thus, vaccination appears to activate both beneficial and deleterious anti\u2010A\u03b2 immunity, suggesting that the vaccine can have potent clinical utility if an appropriate immunologic response can be generated. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.10876","type":"journal-article","created":{"date-parts":[[2004,1,21]],"date-time":"2004-01-21T10:00:45Z","timestamp":1074679245000},"page":"301-306","source":"Crossref","is-referenced-by-count":27,"title":["Anti\u2010A\u03b2: The good, the bad, and the unforeseen"],"prefix":"10.1002","volume":"75","author":[{"given":"Oleg","family":"Broytman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James S.","family":"Malter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,12,10]]},"reference":[{"key":"e_1_2_3_2_1","first-page":"28","volume-title":"Vaccines","author":"Ada G","year":"1999"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(00)00124-X"},{"key":"e_1_2_3_4_1","unstructured":"Alzheimer's Association.2003. 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