{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:23:22Z","timestamp":1790936602744,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2001,8,28]],"date-time":"2001-08-28T00:00:00Z","timestamp":998956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2001,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To date, two subtypes of TrkB, a BDNF receptor, have been described. One is full\u2010length TrkB (TK+), which has a tyrosine kinase\u2010containing intracellular domain. The other is truncated TrkB (TK\u2212), which has a short intracellular domain lacking the tyrosine kinase. In this study, we investigated the dimerization of TrkB subtypes in the developing monkey prefrontal cortex by means of cross\u2010linking. At embryonic day 120, the TK+\/TK+ and the 100 kDa\/100 kDa homodimers were observed with BDNF stimulation. At the newborn stage, the TK+\/TK+ and the TK\u2212\/TK\u2212 homodimers were observed with BDNF stimulation. At the adult stage, the TK\u2212\/TK\u2212 homodimer and the TK+\/TK\u2212 heterodimer were formed by BDNF stimulation. The levels of all dimers increased in proportion to the concentration of BDNF. Moreover, the dimers were clearly formed within 5 min of treatment with BDNF. BDNF and NT\u20104\/5 induced the dimers, whereas NT\u20103 formed slight dimers but NGF did not. Furthermore, anti\u2010BDNF antibody inhibited the TrkB dimerization. Moreover, the intercellular binding proteins of TrkB were not cross\u2010linked by BS3. Therefore, these results suggest that the change in dimerization among TrkB subtypes occurs during development of the monkey prefrontal cortex. J. Neurosci. Res. 65:463\u2013469, 2001. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.1175","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T15:55:21Z","timestamp":1030290921000},"page":"463-469","source":"Crossref","is-referenced-by-count":22,"title":["TrkB dimerization during development of the prefrontal cortex of the 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