{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:33:30Z","timestamp":1759336410735},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2001,10,25]],"date-time":"2001-10-25T00:00:00Z","timestamp":1003968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2001,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this study, the responses of nicotinamide adenine dinucleotide phosphate\u2010diaphorase (NADPH\u2010d) and neuronal nitric oxide synthase (nNOS) activities were quantitatively analyzed at different times in both ipsilateral and contralateral sides of trigeminal nuclei, after unilateral trigeminal muscle nerve transection, in Sprague Dawley rats. In the control animals, both NADPH\u2010d\u2010 and nNOS\u2010positive neurons were constitutively distributed in the rostrolateral solitary tract nucleus, dorsomedial part of trigeminal nucleus oralis (Vo\/Sn), and superficial layers (VcI\/II) of the trigeminal nucleus caudalis (Vc). NADPH\u2010d\u2010positive neurons appeared in the trigeminal mesencephalic nucleus ipsilaterally at 5 days (mean \u00b1 SEM: 30.5 \u00b1 5.6) and were maintained until 8 weeks (33 \u00b1 10.6) after the denervation. In the trigeminal motor nucleus, NADPH\u2010d\u2010positive neurons appeared transiently and bilaterally, peaking at 1 week (663.5 \u00b1 156.2, ipsilateral side; 687.5 \u00b1 118.6, contralateral side) after unilateral denervation of the masseteric nerve. In both Vo\/Sn and Vc, the number of NADPH\u2010d\u2010positive neurons in the control animals showed a decrease at 3 days but significantly increased from 5 days to 1 week and gradually fell to the control values by 8 weeks after the denervation. There were no significant differences observed between the two sides in either Vo\/Sn or Vc. nNOS\u2010positive neurons were similarly distributed and the numbers of labeled neurons were similar to those of NADPH\u2010d\u2010positive neurons after the denervation, although the changes were delayed by approximately 1 week. In conclusion, after unilateral nerve transection, the peak NADPH\u2010d activity occurs 1 week prior to nNOS activity. J. Neurosci. Res. 66:428\u2013438, 2001. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.1235","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T21:15:54Z","timestamp":1030310154000},"page":"428-438","source":"Crossref","is-referenced-by-count":11,"title":["Nitric oxide synthase\/nicotinamide adenine dinucleotide phosphate\u2010diaphorase in the brainstem trigeminal nuclei after transection of the masseteric nerve in 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