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In addition to opioid receptor binding, hemorphins have been shown to have a number of effects on the renin\u2010angiotensin system, including inhibition of angiotensin\u2010converting enzyme and angiotensin IV receptor binding. However, relatively few studies have examined the role of hemorphins in neurological diseases. Here we report the first study of hemorphins in Alzheimer's disease (AD) brains. Quantitative MALDI\u2010TOF mass spectrometry was employed to assess levels of LVV and VV hemorphin\u20106 and \u20107 in 10 control and 10 AD brain tissue samples. LVV hemorphin\u20106 and total hemorphin levels were elevated in AD temporal neocortex but not in hippocampus, occipital lobe, or frontal lobe. The elevation of hemorphins is probably indicative of a vascular abnormality resulting from cerebral amyloid angiopathy associated with both neurodegenerative disease and aging. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.20020","type":"journal-article","created":{"date-parts":[[2004,2,26]],"date-time":"2004-02-26T20:32:05Z","timestamp":1077827525000},"page":"704-714","source":"Crossref","is-referenced-by-count":32,"title":["Quantification of hemorphins in Alzheimer's disease brains"],"prefix":"10.1002","volume":"75","author":[{"given":"Anne","family":"Poljak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catriona 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