{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:03:14Z","timestamp":1760954594173},"reference-count":68,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,3,23]],"date-time":"2004-03-23T00:00:00Z","timestamp":1080000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Antipsychotic (neuroleptic) drugs induce structural alterations in synaptic terminals and changes in the expression of presynaptic protein genes. Whether there are also changes in corresponding postsynaptic (dendritic) markers has not been determined. We describe the effect of 14\u2010day treatment with typical (haloperidol, chlorpromazine) or atypical (clozapine, olanzapine, risperidone) antipsychotics on the expression of two dendritic protein genes, microtubule\u2010associated protein 2 (MAP2) and spinophilin, using in situ hybridization, in the rat hippocampus, retrosplenial, and occipitoparietal cortices. MAP2 mRNA was increased modestly in the dentate gyrus and retrosplenial cortex by chlorpromazine, risperidone, and olanzapine and in the occipitoparietal cortex by chlorpromazine, haloperidol, and risperidone. None of the antipsychotics affected spinophilin mRNA in any area. Overall, these results show a modulation of MAP2 gene expression, likely reflecting functional or structural changes in the dendritic tree in response to some typical and atypical antipsychotics. The lack of change in spinophilin mRNA suggests that dendritic spines are not affected selectively by the drugs. The data provide further evidence that antipsychotics regulate genes involved in synaptic structure and function. Such actions may underlie their long\u2010term effects on neural plasticity in areas of the brain implicated in the pathology of schizophrenia. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.20092","type":"journal-article","created":{"date-parts":[[2004,4,6]],"date-time":"2004-04-06T21:01:43Z","timestamp":1081285303000},"page":"376-382","source":"Crossref","is-referenced-by-count":23,"title":["Antipsychotics increase microtubule\u2010associated protein 2 mRNA but not spinophilin mRNA in rat hippocampus and cortex"],"prefix":"10.1002","volume":"76","author":[{"given":"Amanda J.","family":"Law","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise J.","family":"Hutchinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip W.J.","family":"Burnet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul J.","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,3,23]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.18.9956"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.10093"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.23.10850"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(85)90353-1"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(85)90532-3"},{"key":"e_1_2_5_7_1","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1210\/endo.142.3.8036","article-title":"Novel target sites for estrogen action in the dorsal hippocampus: an examination of synaptic proteins","volume":"142","author":"Brake WG","year":"2001","journal-title":"Endocrinology"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(02)00201-3"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199504190-00019"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2002.01104.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(99)00068-7"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199402000-00004"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000238"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2396(20000601)36:3<167::AID-SYN2>3.0.CO;2-D"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(93)90041-J"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.16.9287"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.65.4.446"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/336674a0"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00021-0"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/10.10.952"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.57.1.65"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(99)00065-1"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/122.4.593"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-003-1761-y"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.1067"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/35104061"},{"key":"e_1_2_5_27_1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/oso\/9780192629074.003.0005","volume-title":"The neuropathology of schizophrenia. Progress and interpretation","author":"Honer WG","year":"2000"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M205754200"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490330402"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(94)90031-0"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/6.3.431"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4927(02)00022-7"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.046987"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(03)00162-0"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)02299-5"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1997.6552"},{"key":"e_1_2_5_37_1","first-page":"51","article-title":"The effects of haloperidol on synaptic plasticity in rat's medial prefrontal cortex","volume":"30","author":"Klintzova AJ","year":"1989","journal-title":"J Hirnforsch"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.3.311"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(01)01267-7"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(98)00130-2"},{"key":"e_1_2_5_41_1","article-title":"Reduced spinophilin but not MAP2 expression in the hippocampal formation in schizophrenia and mood disorder: molecular evidence for a pathology of dendritic spines","author":"Law AJ","year":"2004","journal-title":"Am J Psychiatry"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903390204"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(00)01058-1"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(97)00097-X"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.1991.Supplement_15.9"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)90867-6"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02253587"},{"key":"e_1_2_5_48_1","first-page":"164","volume-title":"Methods in Neuroscience","author":"Miller M","year":"1989"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2990.1999.00163.x"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(98)00230-7"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M209532200"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199802160-00006"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)90401-4"},{"key":"e_1_2_5_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903590104"},{"key":"e_1_2_5_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(93)90460-3"},{"key":"e_1_2_5_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.890200307"},{"key":"e_1_2_5_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(98)00026-6"},{"key":"e_1_2_5_58_1","first-page":"108","article-title":"Structural abnormalities of subicular dendrites in schizophrenia","volume":"53","author":"Rosoklija G","year":"2002","journal-title":"Schizophr Res"},{"key":"e_1_2_5_59_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.57.4.349"},{"key":"e_1_2_5_60_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1996.75.6.2197"},{"key":"e_1_2_5_61_1","doi-asserted-by":"crossref","first-page":"7834","DOI":"10.1523\/JNEUROSCI.19-18-07834.1999","article-title":"Lamina\u2010specific synaptic activation causes domain\u2010specific alterations in dendritic immunostaining for MAP2 and CAM kinase II","volume":"19","author":"Steward O","year":"1999","journal-title":"J Neurosci"},{"key":"e_1_2_5_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/neu.480260316"},{"key":"e_1_2_5_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(89)90309-7"},{"key":"e_1_2_5_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.890070402"},{"key":"e_1_2_5_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00717-1"},{"key":"e_1_2_5_66_1","first-page":"147","article-title":"Evidence for ultrastructural changes in cortical axodendritic synapses following long\u2010term treatment with haloperidol or clozapine","volume":"5","author":"Vincent SL","year":"1991","journal-title":"Neuropsychopharmacology"},{"key":"e_1_2_5_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/0893-133X(94)00081-A"},{"key":"e_1_2_5_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)01064-1"},{"key":"e_1_2_5_69_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.24.1.1071"}],"container-title":["Journal of Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjnr.20092","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.20092","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T20:44:28Z","timestamp":1700167468000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jnr.20092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3,23]]},"references-count":68,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,5]]}},"alternative-id":["10.1002\/jnr.20092"],"URL":"https:\/\/doi.org\/10.1002\/jnr.20092","archive":["Portico"],"relation":{},"ISSN":["0360-4012","1097-4547"],"issn-type":[{"value":"0360-4012","type":"print"},{"value":"1097-4547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,3,23]]}}}