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To define the interaction between PAF and oxidative radicals in neuronal death, we studied the effects of PAF in the presence of oxidative radicals in primary neurons in culture. Exogenous PAF (50 \u03bcM) caused PAF receptor\u2010independent injury to neurons. A nonneurotoxic PAF concentration (500 nM) potentiated neuronal death caused by hydrogen peroxide as determined by lactate dehydrogenase (LDH) assay, Hoechst staining, and TUNEL analysis, but it did not potentiate neuronal death caused by menadione, a superoxide donor, or by the nitric oxide donors 3\u2010morpholino\u2010sydnonimine (SIN\u20101) and sodium nitroprusside (SNP). This potentiation of the hydrogen peroxide effect was selectively blocked by a PAF membrane\u2010receptor antagonist, BN52021 (5 \u03bcM). The neurotoxic effect of PAF and hydrogen peroxide was also completely blocked by ebselen and partially decreased by pretreatment with (S)\u20103,5\u2010dihydroxyphenylglycine (DHPG), a group I metabotropic glutamate receptor (mGluR) agonist. This study suggests that PAF\u2010receptor antagonists may be useful for neuroprotection. A similar effect might also be obtained with group I mGluR agonists, probably by way of a different underlying mechanism. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.20175","type":"journal-article","created":{"date-parts":[[2004,5,27]],"date-time":"2004-05-27T21:02:51Z","timestamp":1085691771000},"page":"525-531","source":"Crossref","is-referenced-by-count":26,"title":["Interplay among platelet\u2010activating factor, oxidative stress, and group I metabotropic glutamate receptors modulates neuronal survival"],"prefix":"10.1002","volume":"77","author":[{"given":"Peimin","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A.","family":"DeCoster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas 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