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Wistar rats were lesioned with 6\u2010OHDA and then treated with MPEP (3 mg\/kg\/day, i.p.) or its vehicle over 2 weeks. Chronic MPEP did not induce measurable antiparkinsonian effects, since no differences were found between MPEP\u2010 and vehicle\u2010treated animals in the pattern of L\u2010DOPA\u2010induced contralateral rotations. In corticostriatal slices taken from animals chronically treated with MPEP, the functional effects of the mGlu5R agonist CHPG were significantly reduced in the lesioned vs. the intact side, while no changes were found in slices taken from vehicle\u2010treated rats. The binding of [<jats:sup>3<\/jats:sup>H]MPEP to striatal membranes showed that neither the maximal number of binding sites (Bmax) nor the dissociation constant (Kd) were changed by the lesion and\/or by chronic MPEP. While chronic MPEP did not potentiate L\u2010DOPA\u2010induced turning in a classical model of PD, its ability to reduce mGlu5R\u2010associated signal could help to explain the neuroprotective\/antiparkinsonian effects observed in other models of PD. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.20489","type":"journal-article","created":{"date-parts":[[2005,5,6]],"date-time":"2005-05-06T19:48:27Z","timestamp":1115408907000},"page":"646-654","source":"Crossref","is-referenced-by-count":22,"title":["Chronic treatment with the mGlu5R antagonist MPEP reduces the functional effects of the mGlu5R agonist CHPG in the striatum of 6\u2010hydroxydopamine\u2010lesioned rats: Possible relevance to the effects of mGlu5R blockade in Parkinson's disease"],"prefix":"10.1002","volume":"80","author":[{"given":"Maria Rosaria","family":"Domenici","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa 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