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Furthermore, angiotensin activates NADPH\u2010dependent oxidases, which are a major source of superoxide, and angiotensin\u2010converting enzyme inhibitors, commonly used in the treatment of hypertension and chronic heart failure, have shown antioxidant properties in several tissues. Oxidative stress is a key contributor to the pathogenesis and progression of Parkinson's disease. In the present study, we treated rats with intraventricular injections of the dopaminergic neurotoxin 6\u2010hydroxydopamine and subcutaneous injections of the angiotensin\u2010converting enzyme inhibitor Captopril to study the possible neuroprotective effect of the latter on the dopaminergic system and on 6\u2010hydroxydopamine\u2010induced oxidative stress. Rats treated with Captopril and 6\u2010hydroxydopamine showed significantly less reduction in the number of dopaminergic neurons (i.e., immunoreactive to tyrosine hydroxylase) in the substantia nigra and in the density of striatal dopaminergic terminals than 6\u2010hydroxydopamine\u2010lesioned rats not treated with Captopril. In addition, Captopril reduced the levels of major oxidative stress indicators (i.e., lipid peroxidation and protein oxidation) in the ventral midbrain and the striatum of 6\u2010hydroxydopamine\u2010lesioned rats. Our results suggest that angiotensin\u2010converting enzyme inhibitors may be useful for treatment of Parkinson's disease and that further investigation should focus on the neuroprotective capacity of these compounds. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.20598","type":"journal-article","created":{"date-parts":[[2005,8,22]],"date-time":"2005-08-22T20:47:07Z","timestamp":1124743627000},"page":"865-873","source":"Crossref","is-referenced-by-count":85,"title":["Angiotensin\u2010converting enzyme inhibition reduces oxidative stress and protects dopaminergic neurons in a 6\u2010hydroxydopamine rat model of 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