{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T02:34:14Z","timestamp":1780108454894,"version":"3.54.0"},"reference-count":53,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,7,27]],"date-time":"2005-07-27T00:00:00Z","timestamp":1122422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2005,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nerve cells may survive or die after axonal or dendritic transection. After neurite transection near (&lt;50 \u03bcm) the cell body of Fura\u20102\u2010loaded B104 neuroblastoma (rat brain\u2010derived) cells, the somal calcium concentration (SCC) undergoes a three\u2010phase transient change: a rapid (0\u20130.15\u2010min posttransection [PT]) rise phase, followed by an early (0.15\u20131.5\u2010min PT) rapid decay phase, and succeeded by a late (1.5\u201360\u2010min PT) slower decay phase that restores SCC to preinjury levels. The SCC in a critical interval (1.5\u201312.5 min PT) of the third transient phase correlates with cell fate, i.e., most transected cells that exclude dye (restore a barrier) and die have a significantly higher (<jats:italic>P<\/jats:italic> &lt; 0.005) SCC in this critical interval than do transected cells that exclude dye and survive at 24\u2010hr PT. Loading BAPTA (chelation of somal Ca<jats:sup>2+<\/jats:sup>) before, but not after, the critical interval increases the percentage of cells that survive compared to that of cells transected without BAPTA loading. Furthermore, most transected cells that die despite successful barrier restoration exhibit characteristics consistent with apoptosis initiated during the critical interval of the SCC, including caspase activation and plasmalemmal phosphatidylserine translocation. These data suggest that decreased cell survival for injuries near the soma is due to Ca<jats:sup>2+<\/jats:sup>\u2010initiated apoptosis during the critical interval of the third phase of the SCC transient. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.20606","type":"journal-article","created":{"date-parts":[[2005,7,27]],"date-time":"2005-07-27T21:53:59Z","timestamp":1122501239000},"page":"805-816","source":"Crossref","is-referenced-by-count":22,"title":["Critical interval of somal calcium transient after neurite transection determines B104 cell survival"],"prefix":"10.1002","volume":"81","author":[{"given":"Michael P.","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George D.","family":"Bittner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harvey M.","family":"Fishman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,7,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00014-1"},{"key":"e_1_2_6_3_1","first-page":"286","article-title":"Calcium\u2010induced spongiform and necrotizing myelopathy","volume":"47","author":"Balentine JD","year":"1982","journal-title":"Lab Invest"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198803000-00001"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.14-07-04368.1994"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.1.514"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5392.1318"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(19991001)58:1<167::AID-JNR16>3.0.CO;2-K"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200103050-00022"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(99)00032-7"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198606263142604"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(96)00273-6"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.9.4745"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0320(19980101)31:1<1::AID-CYTO1>3.0.CO;2-R"},{"key":"e_1_2_6_15_1","first-page":"115","article-title":"Vesicle\u2010mediated restoration of a plasmalemmal barrier after axonal injury","volume":"18","author":"Fishman HM","year":"2003","journal-title":"News Physiol Sci"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2000.0751264.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1996.tb01284.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-10-06445.1995"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)83641-4"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(96)00604-X"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902840206"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-17-06669.1997"},{"key":"e_1_2_6_23_1","volume-title":"Axonal regeneration in the central nervous system","author":"Ingoglia NA","year":"2001"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(00)00256-4"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-12-04656.1998"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1998.71041390.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03401713"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80085-9"},{"key":"e_1_2_6_29_1","first-page":"231","article-title":"Neuronal survival or death after dendritic transection close to the perikaryon: correlation with electrophysiologic, morphologic, and ultrastructural changes","volume":"2","author":"Lucas JH","year":"1985","journal-title":"CNS Trauma"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)00762-2"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1999.0722286.x"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4695(199908)40:2<185::AID-NEU5>3.0.CO;2-#"},{"key":"e_1_2_6_33_1","volume-title":"Design and analysis of experiments","author":"Montgomery DC","year":"2001"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-10-03659.1998"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.60.2.448"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19970203)378:1<10::AID-CNE4>3.0.CO;2-N"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1993.1142"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/254341a0"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/249224a0"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2000.84.4.1763"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902790312"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880130814"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(03)00094-6"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5381.1312"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0143-4160(85)90041-7"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1994.72.4.1973"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.14-09-05417.1994"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-14-05932.1999"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/neu.480240103"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.271.5248.521"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200112040-00008"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.11-10-03257.1991"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-19-07415.1997"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/neu.20005"}],"container-title":["Journal of Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjnr.20606","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.20606","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T14:17:11Z","timestamp":1695910631000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jnr.20606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7,27]]},"references-count":53,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,9,15]]}},"alternative-id":["10.1002\/jnr.20606"],"URL":"https:\/\/doi.org\/10.1002\/jnr.20606","archive":["Portico"],"relation":{},"ISSN":["0360-4012","1097-4547"],"issn-type":[{"value":"0360-4012","type":"print"},{"value":"1097-4547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,7,27]]}}}