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To examine the correlation between the anti\u2010GD3 antibody titer and <jats:italic>Campylobacter jejuni<\/jats:italic> infection, we sensitized female Lewis rats with lipopolysaccharides (LPSs) from serotype HS19 of <jats:italic>C. jejuni<\/jats:italic> and examined changes in nerve conduction velocity and nerve conduction block (P\/D ratio). After 16 weeks of sensitization, animals revealed decreases of nerve conduction velocity and conduction block (P\/D ratio) and high titer of anti\u2010GD3 antibodies. These anti\u2010GD3 antibodies also blocked transmission in neuromuscular junctions of spinal cord\u2010muscle cells cocultures. The GD3 epitope was verified to be located on the Schwann cell surface and nodes of Ranvier in rat sciatic nerve. To determine the target epitope for GD3 antibodies in causing nerve dysfunction, the LPS fraction containing the GD3 epitope was purified from the total LPS by using an anti\u2010GD3 monoclonal antibody\u2010immobilized affinity column. Subsequently, chemical analysis of the oligosaccharide portion was performed and confirmed the presence of a GD3\u2010like epitope as having the following tetrasaccharide structure: NeuAc\u03b12\u20108NeuAc2\u20103Gal\u03b21\u20104Hep. Our data thus support the possibility of a contribution of GD3 mimicry as a potential pathogenic mechanism of peripheral nerve dysfunction. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.20717","type":"journal-article","created":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T00:46:40Z","timestamp":1134089200000},"page":"274-284","source":"Crossref","is-referenced-by-count":23,"title":["Molecular mimicry: Sensitization of Lewis rats with <i>Campylobacter jejuni<\/i> lipopolysaccharides induces formation of antibody toward GD3 ganglioside"],"prefix":"10.1002","volume":"83","author":[{"given":"Seigo","family":"Usuki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart A.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael 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