{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T20:56:32Z","timestamp":1761512192003},"reference-count":71,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,1,6]],"date-time":"2006-01-06T00:00:00Z","timestamp":1136505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2006,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\u03b3\u2010Aminobutyric acid type B (GABA<jats:sub>B<\/jats:sub>) receptors are involved in the modulation of neuronal activity in response to chronic noxious input. However, the effect of their activation in chronic inflammatory pain in relay thalamic nuclei such as the ventrobasal complex (VB) is not known. In this study, experimental groups of 2, 4, and 14 days monoarthritic (MA) rats were injected with saline (controls) or baclofen (0.875 \u03bcg), a specific GABA<jats:sub>B<\/jats:sub> receptor agonist, in the VB contralateral to the inflamed joint, and the ankle\u2010bend test was performed. Ankle\u2010bend scores in control animals were near the maximum and were rather constant throughout the entire experimental period, indicating severe nociception. The same was observed in 2 days MA rats injected with baclofen. In the 4 days MA group, the response to baclofen injection was inconsistent among different animals, whereas, in 14 days MA rats, baclofen caused clear antinociceptive effects. Additionally, a 0.5 \u03bcg dose of baclofen was tested in 14 days MA rats, but no effect was observed, whereas a 1.25 \u03bcg dose produced visible side effects. Baclofen injections that did not target the VB but reached neighboring nuclei were ineffective in reducing nociception. Data demonstrate that the activation of the GABA<jats:sub>B<\/jats:sub> receptors by baclofen in the VB of MA rats leads to a decrease of nociception. Moreover, the response depends on the time course of the disease, suggesting the occurrence of different excitatory states of thalamic VB neurons. In conclusion, GABA<jats:sub>B<\/jats:sub> receptors in the VB play an important role in chronic inflammatory pain processing. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.20737","type":"journal-article","created":{"date-parts":[[2006,1,9]],"date-time":"2006-01-09T20:10:10Z","timestamp":1136837410000},"page":"515-523","source":"Crossref","is-referenced-by-count":30,"title":["Administration of baclofen, a \u03b3\u2010aminobutyric acid type B agonist in the thalamic ventrobasal complex, attenuates allodynia in monoarthritic rats subjected to the ankle\u2010bend test"],"prefix":"10.1002","volume":"83","author":[{"given":"Catarina Soares","family":"Potes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fani Louren\u00e7a","family":"Neto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Manuel","family":"Castro\u2010Lopes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,6]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-6618(02)00147-0"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(98)80059-7"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19990913)412:1<1::AID-CNE1>3.0.CO;2-D"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00000725"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(88)90156-7"},{"key":"e_1_2_5_7_1","first-page":"3","article-title":"Metabotropic GABAB receptors","volume":"15","author":"Bowery NG","year":"1999","journal-title":"Neurotransmissions"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(00)00286-0"},{"key":"e_1_2_5_9_1","first-page":"327","article-title":"The foot\u2010bend procedure as test of nociception for chronic studies in a model of monoarthritis in the rat","volume":"4","author":"Butler SH","year":"1994","journal-title":"Pharmacol Commun"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(92)90133-V"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(00)00262-1"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1992.tb00877.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)00262-O"},{"key":"e_1_2_5_14_1","first-page":"29","volume-title":"Pain: current understanding, emerging therapies, and novel approaches to drug discovery","author":"Cervero F","year":"2003"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(03)03163-9"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2004.04083.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00323.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1152\/jn.1986.56.2.370","article-title":"Response characteristics of neurones in the ventral porterior lateral nucleus of the monkey thalamus","volume":"56","author":"Chung JM","year":"1986","journal-title":"J Neurophysiol"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(83)90086-2"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(93)90161-H"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.2000.0908"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(91)90178-W"},{"key":"e_1_2_5_23_1","first-page":"219","article-title":"Intrathecal baclofen and muscimol,but not midazolam, are antinociceptive using the rat\u2010formalin model","volume":"275","author":"Dirig DM","year":"1995","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(92)90019-5"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)03247-X"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(95)00590-0"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2004.07.018"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(92)90025-4"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(82)90457-7"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)00235-7"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1090-3801(97)90067-7"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1139\/y91-095"},{"key":"e_1_2_5_33_1","first-page":"185","volume-title":"Thalamus and pain","author":"Guilbaud G","year":"1987"},{"key":"e_1_2_5_34_1","first-page":"113","volume-title":"Textbook of pain","author":"Guilbaud G","year":"1994"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(98)00142-6"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.9706"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/25348"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/25360"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.25.14991"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1980.43.6.1594"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1088886"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0953-816x.2001.01855.x"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.283.5398.74"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1997.091bl.x"},{"key":"e_1_2_5_45_1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1152\/jn.1996.75.1.109","article-title":"Role of GABA receptor subtypes in inhibition of primate spinothalamic tract neurones: difference between spinal and periaqueductal gray inhibition","volume":"75","author":"Lin Q","year":"1996","journal-title":"J Neurophysiol"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1177\/026988110201600108"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19990315)405:3<299::AID-CNE2>3.0.CO;2-6"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(95)00012-K"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1998.79.3.1508"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(00)01613-X"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(99)00185-2"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(00)00176-5"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M209532200"},{"key":"e_1_2_5_54_1","first-page":"344","article-title":"Clinical assessment and pharmacologic therapy of spasticity","volume":"55","author":"Pedersen E","year":"1974","journal-title":"Arch Phys Med Rehabil"},{"key":"e_1_2_5_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(80)91125-7"},{"key":"e_1_2_5_56_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1999.00704.x"},{"key":"e_1_2_5_57_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2003.02586.x"},{"key":"e_1_2_5_58_1","volume-title":"GABAB receptor activation in the thalamic ventrobasal complex reduces allodynia in monoarthritic rats","author":"Potes CS","year":"2004"},{"key":"e_1_2_5_59_1","unstructured":"PotesCS NetoFL Castro\u2010LopesJM.2006.Inhibition of pain behaviour by GABABreceptor activation in the thalamic ventrobasal complex: effect on normal rats subjected to the formalin test of nociception. (in press)."},{"key":"e_1_2_5_60_1","first-page":"629","volume-title":"The rat nervous system","author":"Price JL","year":"1995"},{"key":"e_1_2_5_61_1","first-page":"155","article-title":"Central nervous system plasticity and persistent pain","volume":"13","author":"Ren K","year":"1999","journal-title":"J Orofac Pain"},{"key":"e_1_2_5_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(02)00368-8"},{"key":"e_1_2_5_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2004.01.003"},{"key":"e_1_2_5_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-3623(96)00241-8"},{"key":"e_1_2_5_65_1","first-page":"274","article-title":"Microinjection of baclofen in the ventromedial medulla of rats: antinociception at low doses and hyperalgesia at high doses","volume":"275","author":"Thomas DA","year":"1995","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_5_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(96)00100-X"},{"key":"e_1_2_5_67_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021427"},{"key":"e_1_2_5_68_1","first-page":"443","article-title":"Tremor following intracerebral carbachol injection. 1. Carbachol sensitivity of various brain structures","volume":"34","author":"Westermann KH","year":"1975","journal-title":"Acta Biol Med Ger"},{"key":"e_1_2_5_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(96)01015-6"},{"key":"e_1_2_5_70_1","doi-asserted-by":"publisher","DOI":"10.1177\/026988110201600405"},{"key":"e_1_2_5_71_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.25.11756"},{"key":"e_1_2_5_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(83)90201-4"}],"container-title":["Journal of Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjnr.20737","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.20737","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T19:30:57Z","timestamp":1700076657000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jnr.20737"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1,6]]},"references-count":71,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,2,15]]}},"alternative-id":["10.1002\/jnr.20737"],"URL":"https:\/\/doi.org\/10.1002\/jnr.20737","archive":["Portico"],"relation":{},"ISSN":["0360-4012","1097-4547"],"issn-type":[{"value":"0360-4012","type":"print"},{"value":"1097-4547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1,6]]}}}