{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:13:55Z","timestamp":1790723635102,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,2,21]],"date-time":"2006-02-21T00:00:00Z","timestamp":1140480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The inner ear of humans and experimental animals demonstrate an abundance of glucocorticoid receptors (GR). Glucocorticoids (GC) are widely used to treat different hearing disorders; yet the mechanisms of GC action on the inner ear are unknown. We demonstrate how GR can directly modulate hearing sensitivity in response to a moderate acoustic trauma that results in a hearing loss (10\u201330 dB). The GC agonist (dexamethasone) and the drugs (metyrapone + RU 486) showed opposing effects on hearing threshold shifts. GC agonist (dexamethasone) decreased the hearing threshold whereas pre\u2010treatment with a GC synthesis inhibitor (metyrapone) in combination with a GR antagonist (RU 486) exacerbated auditory threshold shifts (25\u201360 dB) after acoustic trauma with statistically significant increase in GR mRNA and GR protein compared with the vehicle and acoustic trauma group. Acoustic trauma caused a significant increase in the nuclear transport of NF\u2010\u03baB, whereas pre\u2010treatment with the drugs (metyrapone and RU 486) blocked NF\u2010\u03baB nuclear transport into spiral ganglion nuclei. An NF\u2010\u03baB inhibitor, pyrrolidine dithiocarbamate ammonium blocked the trauma\u2010induced translocation of NF\u2010\u03baB and resulted in a hearing loss (45\u201360) dB. These results indicate that several factors define the responsiveness of the inner ear to GC, including the availability of ligand or receptor, and the nuclear translocation of GR and NF\u2010\u03baB. These findings will further our understanding of individual GC responsiveness to steroid treatment, and will help improve the development of pharmaceuticals to selectively target GR in the inner ear for individuals with increased sensitivity to acoustic trauma. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.20795","type":"journal-article","created":{"date-parts":[[2006,2,22]],"date-time":"2006-02-22T00:46:35Z","timestamp":1140569195000},"page":"1066-1076","source":"Crossref","is-referenced-by-count":93,"title":["NF\u2010\u03baB mediated glucocorticoid response in the inner ear after acoustic trauma"],"prefix":"10.1002","volume":"83","author":[{"given":"Yeasmin","family":"Tahera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inna","family":"Meltser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Johansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pontus","family":"Stierna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita C.","family":"Hansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Canlon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,2,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00378"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2396(200002)35:2<151::AID-SYN8>3.0.CO;2-P"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.127.3.253"},{"key":"e_1_2_5_5_1","first-page":"4.1.1.","volume-title":"Current protocols in molecular biology","author":"Ausubel FM","year":"2002"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90201-5"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2003.02641.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(95)00207-3"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb08652.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/014556130408300611"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200411000-00031"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(96)00116-3"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489009107417"},{"key":"e_1_2_5_14_1","first-page":"75","article-title":"Pharmacological influence on inner ear endothelial cells in relation to the pathogenesis of sensorineural hearing loss","volume":"59","author":"Gloddek B","year":"2002","journal-title":"Acta Otorhinolaryngol"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.1999.0770"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000059432"},{"key":"e_1_2_5_17_1","doi-asserted-by":"crossref","first-page":"6013","DOI":"10.1523\/JNEUROSCI.23-14-06013.2003","article-title":"c\u2010fos reduces corticosterone\u2010mediated effects on neurotrophic factor expression in the rat hippocampal CA1 region","volume":"23","author":"Hansson AC","year":"2003","journal-title":"J Neurosci"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.14.1875"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20619"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-1759(98)00085-4"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20392"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200407027"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb08645.x"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00386.x"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(02)00190-X"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2004.08.022"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M311766200"},{"key":"e_1_2_5_28_1","first-page":"121","article-title":"Role of brain\u2010derived neurotrophic factor and NF kappaB in neuronal plasticity and survival: from genes to phenotypes","volume":"22","author":"Marini AM","year":"2004","journal-title":"Restor Neurol Neurosci"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11916"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348947908800501"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198405000-00016"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1159\/000080226"},{"key":"e_1_2_5_33_1","first-page":"63","article-title":"Homologous downregulation of the glucocorticoid receptor: the molecular machinery","volume":"3","author":"Oakley RH","year":"1993","journal-title":"Crit Rev Eukaryot Gene Expr"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1690309"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(03)00344-7"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(96)70133-X"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(93)90007-N"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(94)00171-L"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(89)90013-0"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.175.5.1181"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940211101213"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.2144\/96212rr01"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/000164802320396402"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489609137825"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2004.06.003"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199308000-00007"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(00)00218-5"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2005.02.028"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1006\/pupt.2001.0312"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2003.12.003"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.15.1976"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.09.037"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2003.10.037"},{"key":"e_1_2_5_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2004.10.008"}],"container-title":["Journal of Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjnr.20795","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.20795","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T23:10:34Z","timestamp":1696893034000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jnr.20795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2,21]]},"references-count":53,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["10.1002\/jnr.20795"],"URL":"https:\/\/doi.org\/10.1002\/jnr.20795","archive":["Portico"],"relation":{},"ISSN":["0360-4012","1097-4547"],"issn-type":[{"value":"0360-4012","type":"print"},{"value":"1097-4547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,2,21]]}}}