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Adult mice were fed a rodent chow diet either ad libitum (AL) or restricted to reduce body weight by 15\u201318% (CR). Although GM2 and GA2 were elevated, no significant differences were seen between the <jats:italic>Hexb<\/jats:italic>\u2212\/\u2212 and the <jats:italic>Hexb<\/jats:italic>+\/\u2212 mice for most brain phospholipids and cholesterol. Cerebrosides and sulfatides were reduced in the <jats:italic>Hexb<\/jats:italic>\u2212\/\u2212 mice. In addition, rotorod performance was significantly worse in the <jats:italic>Hexb<\/jats:italic>\u2212\/\u2212 mice than in the <jats:italic>Hexb<\/jats:italic>+\/\u2212 mice. CR, which decreased circulating glucose and elevated ketone bodies, significantly improved rotorod performance and extended longevity in the <jats:italic>Hexb<\/jats:italic>\u2212\/\u2212 mice but had no significant effect on brain lipid composition or on cytoplasmic neuronal vacuoles. The expression of CD68 and F4\/80 was significantly less in the CR\u2010fed than in the AL\u2010fed <jats:italic>Hexb<\/jats:italic>\u2212\/\u2212 mice. We suggest that the CR delays disease progression in SD and possibly in other ganglioside storage diseases through anti\u2010inflammatory mechanisms. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.20798","type":"journal-article","created":{"date-parts":[[2006,3,7]],"date-time":"2006-03-07T20:54:59Z","timestamp":1141764899000},"page":"1028-1038","source":"Crossref","is-referenced-by-count":35,"title":["Influence of caloric restriction on motor behavior, longevity, and brain lipid composition in Sandhoff disease mice"],"prefix":"10.1002","volume":"83","author":[{"given":"Christine A.","family":"Denny","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie L.","family":"Kasperzyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen N.","family":"Gorham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roderick 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