{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:43:01Z","timestamp":1790476981857,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,3,6]],"date-time":"2006-03-06T00:00:00Z","timestamp":1141603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acoustic overstimulation induces calcium overload and activation of mitochondria\u2010mediated cell death pathways in outer hair cells (OHC) of the cochlea. However, it is not known whether these events are interrelated or independent. We have recently reported that the calcium\u2010dependent phosphatase calcineurin is activated in OHC following noise exposure and now postulate that calcium overload triggers mitochondria\u2010mediated death pathways through activation of Bcl\u20102\u2010associated death promoter (BAD) by calcineurin. CBA\/J mice were exposed to broadband noise (2\u201320 kHz), causing a permanent threshold shift of about 40 dB at 12 and 20 kHz, corresponding to damage in the middle and basal turns of the cochlea. Loss of OHC in the basal region was evident in surface preparations. BAD immunostaining in control animals had a cytoplasmic distribution in the cells of the organ of Corti. Five hours after acoustic overstimulation, mitochondria and BAD redistributed to the perinuclear region of OHC in the basal and middle turns but not in the apical turn. The nonapoptotic phospho\u2010BAD (Ser 112) was up\u2010regulated in cells undamaged by noise (supporting cells and inner hair cells) but not in OHC. These data establish a connection between calcium overload and mitochondria\u2010mediated death pathways in OHC and also suggest a dual role for BAD. The translocation of BAD to the mitochondria in degenerating cells is indicative of the activation of its proapoptotic capacity, whereas up\u2010regulation of phospho\u2010BAD is consistent with a nonapoptotic role of BAD in less vulnerable cells. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.20832","type":"journal-article","created":{"date-parts":[[2006,3,7]],"date-time":"2006-03-07T20:55:08Z","timestamp":1141764908000},"page":"1564-1572","source":"Crossref","is-referenced-by-count":68,"title":["A BAD link to mitochondrial cell death in the cochlea of mice with noise\u2010induced hearing loss"],"prefix":"10.1002","volume":"83","author":[{"given":"M. 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