{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:17:57Z","timestamp":1791217077455,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,3,31]],"date-time":"2006-03-31T00:00:00Z","timestamp":1143763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Accumulating evidence indicates an immunosuppressive role for CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>+<\/jats:sup> regulatory T cells (Tregs) in autoimmune diseases. Although an impaired Treg function in patients with relapsing\u2010remitting multiple sclerosis (RR\u2010MS) has been reported recently, no information is available so far about Treg function in the progressive stage of the disease. In the present study, the phenotypic and functional characteristics of CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>+<\/jats:sup> T cells isolated from the peripheral blood of patients with RR\u2010MS and secondary progressive multiple sclerosis (SP\u2010MS) were investigated. No significant quantitative or phenotypic abnormalities in CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>+<\/jats:sup> T cells from RR\u2010 and SP\u2010MS patients were detected. However, whereas a reduced suppressor function of CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>+<\/jats:sup> T cells toward proliferation and interferon\u2010\u03b3 production of CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>\u2013<\/jats:sup> responder T cells was found in RR\u2010MS patients, SP\u2010MS patients showed a normal Treg function. The suppressive capacity of MS\u2010derived CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>+<\/jats:sup> T cells was correlated with disease duration but not with age, indicating that Treg function is more affected in the early phase of the disease process. Consistently with the suppressive capacity, CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>+<\/jats:sup> T cells from SP\u2010MS patients showed normal levels of FOXP3 mRNA in contrast to RR\u2010MS patients that had a reduced FOXP3 expression. These data are the first to demonstrate differences in function and FOXP3 expression of CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>+<\/jats:sup> T cells from patients with RR\u2010 and SP\u2010MS. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.20852","type":"journal-article","created":{"date-parts":[[2006,3,31]],"date-time":"2006-03-31T21:16:35Z","timestamp":1143839795000},"page":"1432-1446","source":"Crossref","is-referenced-by-count":157,"title":["Secondary progressive in contrast to relapsing\u2010remitting multiple sclerosis patients show a normal CD4<sup>+<\/sup>CD25<sup>+<\/sup> regulatory T\u2010cell function and FOXP3 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