{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T08:29:48Z","timestamp":1759048188066},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,7,31]],"date-time":"2006-07-31T00:00:00Z","timestamp":1154304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>High antibody affinity has been proposed as a disease determinant factor in neuropathies associated with anti\u2010GM<jats:sub>1<\/jats:sub> antibodies. An experimental model of Guillain\u2010Barr\u00e9 syndrome, induced by immunization of rabbits with bovine brain gangliosides or GM<jats:sub>1<\/jats:sub>, was described recently (Yuki et al. [<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#bib36\">2001<\/jats:ext-link>] Ann. Neurol. 49:712\u2013720). We searched plasma from these rabbits, taken at disease onset and 1 or 2 weeks prior to onset, for the presence of high\u2010affinity anti\u2010GM<jats:sub>1<\/jats:sub> IgG antibodies. Affinity was estimated by soluble antigen binding inhibition. High\u2010affinity antibodies (binding inhibition by 10<jats:sup>\u20139<\/jats:sup> M GM<jats:sub>1<\/jats:sub>) were detected at disease onset but not before. No such difference was found for other antibody parameters such as titer, fine specificity, and population distribution. These findings support the proposed role of high affinity as an important factor in disease induction by anti\u2010GM<jats:sub>1<\/jats:sub> antibodies. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.21004","type":"journal-article","created":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T22:48:06Z","timestamp":1154472486000},"page":"1085-1090","source":"Crossref","is-referenced-by-count":22,"title":["High affinity of anti\u2010GM<sub>1<\/sub> antibodies is associated with disease onset in experimental neuropathy"],"prefix":"10.1002","volume":"84","author":[{"given":"Romina","family":"Com\u00edn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhiro","family":"Yuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo H.H.","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo 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