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The Flinders\u2010sensitive line (FSL) rat represents a genetic model of depression with characterized 5\u2010HT and NPY abnormalities in the hippocampus. Consequently, it could be hypothesized that hippocampal neurogenesis in the FSL rat would be impaired. The present study examined the relationship among 1) number of BrdU\u2010immunoreactive (IR) cells, 2) NPY\u2010IR cells in the dentate gyrus, and 3) length of 5\u2010HT\u2010IR fibers in the dorsal hippocampus, as well as volume and number of 5\u2010HT\u2010IR cells in the dorsal raph\u00e9 nucleus, in adult and aged FSL rats and control Flinders\u2010resistant line (FRL) rats. Surprisingly, adult FSL rats had significantly more BrdU\u2010IR and NPY\u2010IR cells compared with adult FRL rats. However, aging caused an exacerbated loss of these cell types in the FSL strain compared with FRL. The aged FSL rats also had shortened 5\u2010HT\u2010IR fibers in the dorsal hippocampus, indicative of an impaired 5\u2010HT innervation of this area, compared with FRL. These results suggest that, for \u201cdepressed\u201d FSL rats, compared with FRL rats, aging is associated with an excacerbated loss of newly formed cells in addition to NPY\u2010IR cells and 5\u2010HT\u2010IR dendrites in the hippocampus. These observations may be of relevance to the depression\u2010like behavior of the FSL rat and, by inference, to the pathophysiology of depression. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.21027","type":"journal-article","created":{"date-parts":[[2006,9,5]],"date-time":"2006-09-05T20:51:28Z","timestamp":1157489488000},"page":"1292-1302","source":"Crossref","is-referenced-by-count":31,"title":["Exacerbated loss of cell survival, neuropeptide Y\u2010immunoreactive (IR) cells, and serotonin\u2010IR fiber lengths in the dorsal hippocampus of the aged flinders sensitive line \u201cdepressed\u201d rat: Implications for the pathophysiology of depression?"],"prefix":"10.1002","volume":"84","author":[{"given":"H.","family":"Husum","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Aznar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"H\u00f8yer\u2010Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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