{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T16:02:32Z","timestamp":1781539352833,"version":"3.54.5"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,10,4]],"date-time":"2006-10-04T00:00:00Z","timestamp":1159920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The phenotype of <jats:italic>Wld<jats:sup>S<\/jats:sup><\/jats:italic> (\u201cslow Wallerian degeneration\u201d) mice demonstrates prolonged survival of injured axons. However, whether the <jats:italic>Wld<jats:sup>S<\/jats:sup><\/jats:italic> mutation delays degeneration of the neuronal cell body following axonal injury is unclear. We used a retrograde model of axonal transport failure in <jats:italic>Wld<jats:sup>S<\/jats:sup><\/jats:italic> mice to test whether the mutant <jats:italic>Wld<jats:sup>S<\/jats:sup><\/jats:italic> protein has any beneficial effect on the neuronal cell body. Retrograde axonal transport was physically blocked by optic nerve crush and confirmed by the absence of Fluoro\u2010Gold labeling in wild\u2010type and in <jats:italic>Wld<jats:sup>S<\/jats:sup><\/jats:italic> mice. After this axonal injury, there was marked protection of axonal degeneration in the <jats:italic>Wld<jats:sup>S<\/jats:sup><\/jats:italic> phenotype, as confirmed by immunohistochemistry and electron microscopy. However, the <jats:italic>Wld<jats:sup>S<\/jats:sup><\/jats:italic> protein, localized in the nucleus of retinal ganglion cells, did not prevent or delay degeneration of the retinal ganglion cell body, confirmed by TUNEL staining and Fluoro\u2010Gold labeling. These results imply that, after axonal injury, Wallerian degeneration of axons and degeneration of the neuronal cell body have different mechanisms, which are autonomous and independent of each other. Although the <jats:italic>Wld<jats:sup>S<\/jats:sup><\/jats:italic> phenotype can be used to demonstrate stable enucleate axons, the mutation is unlikely to protect neurons in neurodegenerative diseases in which there is failure of retrograde transport. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.21075","type":"journal-article","created":{"date-parts":[[2006,10,4]],"date-time":"2006-10-04T17:51:44Z","timestamp":1159984304000},"page":"1799-1807","source":"Crossref","is-referenced-by-count":21,"title":["Degeneration of neuronal cell bodies following axonal injury in <i>Wld<sup>S<\/sup><\/i> mice"],"prefix":"10.1002","volume":"84","author":[{"given":"Ai Ling","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur H.","family":"Neufeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,10,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-6-6"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1994.1234"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.WCB.0000095798.98378.34"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01195555"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.00-0666fje"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200501085"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(92)90160-M"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1989.tb00771.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn770"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(02)00059-3"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1990.tb00472.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1991.tb00815.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1068613"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-004-0952-x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2004.01.053"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-07-02833.2003"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1385\/NMM:5:3:193"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10039"}],"container-title":["Journal of Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjnr.21075","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.21075","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T19:03:02Z","timestamp":1697137382000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jnr.21075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,4]]},"references-count":18,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1002\/jnr.21075"],"URL":"https:\/\/doi.org\/10.1002\/jnr.21075","archive":["Portico"],"relation":{},"ISSN":["0360-4012","1097-4547"],"issn-type":[{"value":"0360-4012","type":"print"},{"value":"1097-4547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,4]]}}}