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Then clioquinol (CQ), an iron chelator that reduces hydroxyl radical production, was orally administrated. Injection of different doses of Type IV collagenase (1.4 \u03bcl 1\u2013200 U\/ml) into the left striatum near the IC in Wistar rats showed that injection of 7.5 U\/ml collagenase resulted in a small hemorrhoidal lesion near the IC with relatively severe motor dysfunction (IC model). Retrograde labeling of neurons in the sensory\u2010motor cortex and axons in the corticospinal tract using Fluoro\u2010gold (FG) injection into the spinal cord (C3\u2013C4) showed that few labeled neurons in the sensory\u2010motor cortex were detected in the IC model, FG\u2010labeled axons disappeared, and FG\u2010including ED\u20101\u2010positive cells appeared within 24 hr in the IC. Assessments of behavior and histologic analysis after oral administration of CQ in the IC model indicated that oral administration of CQ prevented a decrease of FG\u2010labeled neurons, and resulted in better motor\u2010function recovery. CQ inhibited hydrogen peroxide\u2010induced cell toxicity in oligodendrocytes in vitro, but not in neurons. Our data suggests that CQ ameliorated motor dysfunction after a small hemorrhage near the IC by a mechanism that is related to reduction of chain\u2010reactive hydroxyl radical production in oligodendrocytes. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.21089","type":"journal-article","created":{"date-parts":[[2006,10,24]],"date-time":"2006-10-24T13:05:37Z","timestamp":1161695137000},"page":"213-222","source":"Crossref","is-referenced-by-count":46,"title":["Oral administration of metal chelator ameliorates motor dysfunction after a small hemorrhage near the internal capsule in 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