{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T11:43:17Z","timestamp":1771328597459,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,11,27]],"date-time":"2006-11-27T00:00:00Z","timestamp":1164585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the peripheral taste system, activated macrophages are recruited to both sides of the tongue after unilateral sectioning of the chorda tympani nerve (CT). Neural degeneration elicits macrophage entry in other systems by upregulating vascular adhesion molecules. We hypothesized that CT sectioning leads to a bilateral increase in intracellular adhesion molecule (ICAM)\u20101 and vascular cell adhesion molecule (VCAM)\u20101 expression on lingual vessels. To test this hypothesis, rats were euthanized at time points from 6 hr to 7 days post\u2010sectioning. Frozen sections of tongue were processed for immunohistochemical staining for ICAM\u20101 and VCAM\u20101. Tongue homogenates from additional rats were analyzed with ELISA. ICAM\u20101 expression increases first on the denervated side of the tongue at 24 hr post\u2010section and then on the uninjured side at 48 hr post\u2010section. ICAM\u20101 remains elevated through Day 7 post\u2010sectioning on both sides of the tongue. Dietary sodium restriction, which prevents the macrophage response to nerve sectioning, had no effect on ICAM\u20101 levels. VCAM\u20101+ vessels are increased on the denervated side of the tongue at 24\u201348 hr post\u2010section in control\u2010fed rats. However, dietary sodium restriction prevents the increase. These results indicate that vascular adhesion molecules are differentially regulated by CT sectioning. We suggest that macrophage entry, migration, and modulation of taste function are downstream of dynamic expression of adhesion molecules. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.21128","type":"journal-article","created":{"date-parts":[[2006,11,28]],"date-time":"2006-11-28T03:25:31Z","timestamp":1164684331000},"page":"364-372","source":"Crossref","is-referenced-by-count":8,"title":["Upregulation of intracellular adhesion molecule (ICAM)\u20101 and vascular cell adhesion molecule (VCAM)\u20101 after unilateral nerve injury in the peripheral taste system"],"prefix":"10.1002","volume":"85","author":[{"given":"Melissa Ann","family":"Cavallin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynnette Phillips","family":"McCluskey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,11,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2004.02.004"},{"key":"e_1_2_6_3_1","first-page":"469","article-title":"Contribution of ICAM\u20101 and VCAM\u20101 to the morphological changes in monocytes bound to human venous endothelial cells stimulated with recombinant interleukin\u20104 (rIL\u20104) or rIL\u20101 alpha","volume":"77","author":"Beekhuizen H","year":"1992","journal-title":"Immunology"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-6-6"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01179819"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(96)04569-7"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(96)00105-4"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20438"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901720405"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000106321.63667.24"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/520353"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(95)05729-3"},{"key":"e_1_2_6_13_1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.4049\/jimmunol.137.1.245","article-title":"Induction by IL 1 and interferon\u2010gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM\u20101)","volume":"137","author":"Dustin ML","year":"1986","journal-title":"J Immunol"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1054\/tice.1998.0017"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200425327"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20411"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.1999.tb00231.x"},{"key":"e_1_2_6_18_1","first-page":"63","volume-title":"Degeneration and regeneration of taste buds. Handbook of sensory physiology 4: chemical senses","author":"Guth L","year":"1971"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.6_Suppl_6.S22"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-19-08607.2002"},{"key":"e_1_2_6_21_1","doi-asserted-by":"crossref","first-page":"2904","DOI":"10.1523\/JNEUROSCI.14-05-02904.1994","article-title":"Functional plasticity of regenerated and intact taste receptors in adult rats unmasked by dietary sodium restriction","volume":"14","author":"Hill DL","year":"1994","journal-title":"J Neurosci"},{"key":"e_1_2_6_22_1","first-page":"1267","article-title":"Effects of beta\u2010aescin on apoptosis induced by transient focal cerebral ischemia in rats","volume":"25","author":"Hu XM","year":"2004","journal-title":"Acta Pharmacol Sin"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1375"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.4.1259"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1229"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2004.05.034"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-2427(91)90012-2"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63230-0"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.13.2.197"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(97)00063-5"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1006\/cimm.1998.1241"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20307"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00282.2002"},{"key":"e_1_2_6_34_1","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.4049\/jimmunol.152.4.1915","article-title":"Monocytes use either CD11\/CD18 or VLA\u20104 to migrate across human endothelium in vitro","volume":"152","author":"Meerschaert J","year":"1994","journal-title":"J Immunol"},{"key":"e_1_2_6_35_1","doi-asserted-by":"crossref","first-page":"4099","DOI":"10.4049\/jimmunol.154.8.4099","article-title":"The adhesion molecules used by monocytes for migration across endothelium include CD11a\/CD18, CD11b\/CD18, and VLA\u20104 on monocytes and ICAM\u20101, VCAM\u20101, and other ligands on endothelium","volume":"154","author":"Meerschaert J","year":"1995","journal-title":"J Immunol"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091810309"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117410"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.shk.0000223133.10254.82"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.02-1324"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.900330204"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90775-7"},{"key":"e_1_2_6_42_1","first-page":"R857","article-title":"Novel regulation of peripheral gustatory function by the immune system","volume":"271","author":"Phillips LM","year":"1996","journal-title":"Am J Physiol"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2003.11.015"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-002-0541-9"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2004.05.011"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:NEUR.0000030695.76840.19"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.1999.tb00229.x"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.19.2.393"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(98)00147-8"},{"key":"e_1_2_6_50_1","doi-asserted-by":"crossref","first-page":"6825","DOI":"10.4049\/jimmunol.161.12.6825","article-title":"Interaction of very late antigen\u20104 with VCAM\u20101 supports transendothelial chemotaxis of monocytes by facilitating lateral migration","volume":"161","author":"Weber C","year":"1998","journal-title":"J Immunol"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004410100393"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/59.4.B316"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-0849fje"}],"container-title":["Journal of Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjnr.21128","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.21128","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T09:01:31Z","timestamp":1696928491000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jnr.21128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,27]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["10.1002\/jnr.21128"],"URL":"https:\/\/doi.org\/10.1002\/jnr.21128","archive":["Portico"],"relation":{},"ISSN":["0360-4012","1097-4547"],"issn-type":[{"value":"0360-4012","type":"print"},{"value":"1097-4547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,27]]}}}