{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T11:21:42Z","timestamp":1774869702429,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,12,20]],"date-time":"2006-12-20T00:00:00Z","timestamp":1166572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2007,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mitogen\u2010associated protein kinase (MAPK)\u2010 and protein kinase A (PKA)\u2010dependent signal transductions play important roles in the regulation of gene expression. Both MAPK and PKA pathways can be activated by light exposure. In this study, we investigated the effect of light on MAPK and PKA signal transduction and their roles in the regulation of rhodopsin promoter expression by using transgenic zebrafish [Tg(rhod::GFP)]. The Tg(rhod::GFP) fish express short half\u2010life GFP that is under the transcriptional control of the zebrafish rhodopsin promoter and can therefore be used for in vivo studies of rhodopsin gene transcription in live cells. Blue light plays a role in the regulation of rhodopsin promoter expression via an MAPK\u2010mediated signal transduction cascade. Blue light excites cryptochromes (CRY), which activate the downstream PKC\u2010dependent MAPK signal pathway. White light, on the other hand, regulates rhodopsin promoter expression via a G\u2010protein\u2010coupled cAMP\u2010dependent PKA pathway. White light promotes dopamine release in the retina, which activates dopamine receptors and the downstream PKA pathway. Blocking MAPK signaling diminishes the blue light\u2010induced increases in rhodopsin promoter expression, but this treatment has no effect on white light\u2010mediated rhodopsin promoter expression. Conversely, blocking the PKA pathway diminishes the white light\u2010induced rhodopsin promoter expression but does not affect rhodopsin promoter expression regulated by blue light. Together, the data suggest that MAPK and PKA regulate rhodopsin transcription through parallel signal transduction pathways. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.21157","type":"journal-article","created":{"date-parts":[[2006,12,21]],"date-time":"2006-12-21T01:17:19Z","timestamp":1166663839000},"page":"488-496","source":"Crossref","is-referenced-by-count":12,"title":["Mitogen\u2010associated protein kinase\u2010 and protein kinase A\u2010dependent regulation of rhodopsin promoter expression in zebrafish rod photoreceptor cells"],"prefix":"10.1002","volume":"85","author":[{"given":"Chuan\u2010Jiang","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Callie 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