{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T07:21:30Z","timestamp":1789888890337,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,2,15]],"date-time":"2007-02-15T00:00:00Z","timestamp":1171497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Multiple sclerosis (MS) is a common autoimmune neurodegenerative disease of unknown cause, which results in inflammation and plaques of demyelination in brain and eventual axonal degeneration. We report the novel presence of oxidized phosphatidylcholine [1\u2010palmitoyl\u20102\u2010(5\u2032\u2010oxo)valeryl\u2010sn\u2010glycero\u20103\u2010phosphorylcholine (POVPC)], a lipid associated with inflammatory diseases such as atherosclerosis and lung disease, in the brain of MS patients. The OxPC epitope was detected by Western blotting with the E06 monoclonal antibody. E06\u2010positive lipid was present in the highest amounts in MS plaques, which also showed evidence of low\u2010molecular\u2010weight (15\u2010kDa) OxPC\u2010modified protein. E06 reactivity did not change with post\u2010mortem interval, and E06\u2010positive lipids were largely absent from control tissue. We then used a second monoclonal antibody (AB1\u20102, which recognizes the E06\/T15 idiotype and therefore detects the presence of antibody to OxPC) to show that MS brain samples were strongly positive for the 50\u2010kDa antibody heavy chain. We also showed that isoelectric focussing of the oligoclonal IgG characteristic of MS revealed some immunoglobulin bands that Western blotted with the AB1\u20102 antibody. Spinal cords from mice induced to undergo experimental allergic encephalomyelitis (EAE) also showed strong AB1\u20102 reactivity by both immunocytochemistry and Western blot analysis. We therefore conclude that we can detect both OxPC and 15\u2010kDa protein modified by OxPC and the antibody to the antibody to OxPC (antiidiotype) in pathological tissue and suggest that this could play a role in the progression of MS. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.21206","type":"journal-article","created":{"date-parts":[[2007,2,15]],"date-time":"2007-02-15T22:39:55Z","timestamp":1171579195000},"page":"977-984","source":"Crossref","is-referenced-by-count":96,"title":["Oxidized phosphatidylcholine is a marker for neuroinflammation in multiple sclerosis brain"],"prefix":"10.1002","volume":"85","author":[{"given":"J.","family":"Qin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Goswami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Balabanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Dawson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,2,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2004.09.004"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.wco.0000236612.66839.a2"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1999.01009.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1102-1218"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20587"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M400496-JLR200"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20031763"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2004.08.004"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320310624"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M310425200"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M108860200"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra052130"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)32391-9"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830111106"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000116835"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200500086"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-9877(92)90121-R"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(98)00019-7"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64677-9"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M306088200"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00220.2003"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.176.1.303"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx049767l"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830250723"},{"key":"e_1_2_6_26_1","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1093\/clinchem\/38.12.2449","article-title":"Studies of lipid peroxidation products in cerebrospinal fluid and serum in multiple sclerosis and other conditions","volume":"38","author":"Naidoo R","year":"1992","journal-title":"Clin Chem"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200511-1737OC"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(87)90066-X"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI8472"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.1999.tb00212.x"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-004-7028-0"},{"key":"e_1_2_6_32_1","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1177\/135245859800400503","article-title":"Oxidative damage to DNA in plaques of MS brain","volume":"4","author":"Vatassery GT","year":"1998","journal-title":"Mult Scler"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.341.11.1"}],"container-title":["Journal of Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjnr.21206","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.21206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T20:29:30Z","timestamp":1697660970000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jnr.21206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2,15]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["10.1002\/jnr.21206"],"URL":"https:\/\/doi.org\/10.1002\/jnr.21206","archive":["Portico"],"relation":{},"ISSN":["0360-4012","1097-4547"],"issn-type":[{"value":"0360-4012","type":"print"},{"value":"1097-4547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,2,15]]}}}