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We found a reduction of interleukin\u20101\u03b2, tumor necrosis factor\u2010\u03b1, soluble ICAM\u20101, neutrophil counts, and activity after 2 hr of hypoxia, but not with 90 min of hypoxia. By contrast, a significant reduction of apoptosis was seen in animals treated after 90 min of hypoxia but not in those treated after 2 hr of hypoxia. Overall evidence of an inflammatory response was sparse, with low levels of ICAM\u20101 expression and neutrophil recruitment even in the more severe hypoxic ischemic injury. It is likely that the decoy oligonucleotide affects cerebral injury and apoptosis not through suppression of downstream elements of the inflammatory response but through other mechanisms, one of which is the reduction of transcription and synthesis of cytokines, which are known to affect other responses to cellular injury. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.21253","type":"journal-article","created":{"date-parts":[[2007,3,8]],"date-time":"2007-03-08T23:42:24Z","timestamp":1173397344000},"page":"1420-1426","source":"Crossref","is-referenced-by-count":10,"title":["A decoy oligonucleotide inhibiting nuclear factor\u2010\u03baB binding to the IgG\u03baB consensus site reduces cerebral injury and apoptosis in neonatal hypoxic\u2010ischemic encephalopathy"],"prefix":"10.1002","volume":"85","author":[{"given":"Roderic H.","family":"Fabian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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