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STOP null mice have therefore been proposed as an animal model for the study of schizophrenia. In the present study, the expression pattern of STOP gene in developing and adult brain has been examined by using lacZ gene inserted in the STOP locus, as a reporter gene. \u03b2\u2010Galactosidase (\u03b2\u2010gal) immunostaining was confined to neuronal cells and projections. Strong labeling was observed in the whole olfactory system, cortical layer VII, hippocampus, hypothalamus, cerebellum, habenula, fasciculus retroflexus, and interpeduncular nucleus in adults. Additionally, ventral thalamic nucleus, clusters of positive cells in striatum, and Cajal\u2010Retzius cells of cortical layer I were labeled in young mice. The strong expression of STOP lacZ reporter gene observed in brain is confined to areas that may be involved in the schizophrenia\u2010related symptoms observed in STOP\u2010deficient mice. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.21278","type":"journal-article","created":{"date-parts":[[2007,3,30]],"date-time":"2007-03-30T00:18:24Z","timestamp":1175213904000},"page":"1515-1527","source":"Crossref","is-referenced-by-count":23,"title":["Expression pattern of stop lacZ reporter gene in adult and developing mouse brain"],"prefix":"10.1002","volume":"85","author":[{"given":"Alice","family":"Cou\u00e9gnas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Schweitzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Andrieux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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