{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T12:34:08Z","timestamp":1789216448892,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2007,4,4]],"date-time":"2007-04-04T00:00:00Z","timestamp":1175644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2007,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of this study was to determine the long\u2010term effects of polyethylene glycol (PEG) and magnesium sulfate (MgSO<jats:sub>4<\/jats:sub>) on clinically relevant motor, sensory, and autonomic outcomes after spinal cord injury (SCI). Rats were injured by clip compression (50 g; T4) and treated 15 min and 6 hr postinjury intravenously (tail vein) with PEG (1 g\/kg, 30% w\/w in saline; n = 11), MgSO<jats:sub>4<\/jats:sub> (300 mg\/kg; n = 5), PEG + MgSO<jats:sub>4<\/jats:sub> (n = 6), or saline (n = 10). Behavioral testing lasted for 6 weeks, followed by histological analysis of the spinal cord. Both PEG and MgSO<jats:sub>4<\/jats:sub> resulted in enhanced locomotor recovery and lower susceptibility to neuropathic pain (mechanical allodynia) compared with saline. At 6 weeks, BBB scores were 7.3 \u00b1 0.2, 7.7 \u00b1 0.4, and 6.4 \u00b1 0.6 in PEG\u2010treated, MgSO<jats:sub>4<\/jats:sub>\u2010treated, and saline\u2010treated control groups, respectively. Likewise, at 6 weeks PEG\u2010, MgSO<jats:sub>4<\/jats:sub>\u2010, and saline\u2010treated control animals showed 3.5 \u00b1 0.4, 2.8 \u00b1 0.9, and 5.0 \u00b1 0.5 avoidance responses to at\u2010level touch, respectively. PEG + MgSO<jats:sub>4<\/jats:sub> improved locomotor recovery and reduced pain but did not provide additional benefit compared with either treatment alone. Neither treatment, nor their combination, attenuated mean arterial pressure (MAP) increases during autonomic dysreflexia. However, saline\u2010treated controls had significantly lower resting MAP than PEG\u2010treated rats and tended to have lower resting MAP than MgSO<jats:sub>4<\/jats:sub>\u2010treated rats 6 weeks postinjury. MgSO<jats:sub>4<\/jats:sub> treatment and PEG + MgSO<jats:sub>4<\/jats:sub> treatment resulted in significant increases in dorsal myelin sparing, and the latter resulted in significant reductions in lesion volume, compared with saline\u2010treated controls. Furthermore, mean lesion volumes correlated negatively with the corresponding mean BBB scores and positively with the corresponding mean pain scores. In conclusion, both PEG and MgSO<jats:sub>4<\/jats:sub> enhanced long\u2010term clinical outcomes after SCI. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.21283","type":"journal-article","created":{"date-parts":[[2007,4,5]],"date-time":"2007-04-05T02:00:39Z","timestamp":1175738439000},"page":"1458-1467","source":"Crossref","is-referenced-by-count":62,"title":["Effects of polyethylene glycol and magnesium sulfate administration on clinically relevant neurological outcomes after spinal cord injury in the rat"],"prefix":"10.1002","volume":"85","author":[{"given":"David S.","family":"Ditor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil M.","family":"John","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josee","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey 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