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We have previously shown that a population SMN complexes contain Gemin ribonucleoproteins and traffic in the form of granules to neuronal processes and growth cones of cultured neurons. A QNQKE sequence within exon 7 has been shown to be necessary for both cytoplasmic localization of SMN and axonal function. Here we show that the QNQKE sequence can influence the nucleocytoplasmic distribution of the SMN\u2010Gemin complex and its localization into neuronal processes. QNQKE exerted a stronger effect on SMN localization in primary neurons compared with COS\u20107 cells. By using double\u2010label fluorescence in situ hybridization and immunofluorescence, SMN granules within neuronal processes colocalized with poly\u2010(A) mRNA and PABP. These findings provide further evidence in support of a neuronal function for SMN and motivation to investigate for impaired assembly and\/or localization of mRNP complexes as an underlying cause of SMA. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.21308","type":"journal-article","created":{"date-parts":[[2007,4,24]],"date-time":"2007-04-24T15:57:22Z","timestamp":1177430242000},"page":"2657-2667","source":"Crossref","is-referenced-by-count":35,"title":["QNQKE targeting motif for the SMN\u2010Gemin multiprotein complexin neurons"],"prefix":"10.1002","volume":"85","author":[{"given":"Honglai","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H.","family":"Singer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary 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