{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T05:19:06Z","timestamp":1712207946812},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2007,6,4]],"date-time":"2007-06-04T00:00:00Z","timestamp":1180915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2007,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Because there is a strong correlation between tuberous sclerosis and autism, we used a tuberous sclerosis model (Eker rat) to test the hypothesis that these animals would have an altered regional cerebral O<jats:sub>2<\/jats:sub> consumption that might be associated with autism. We also examined whether the altered cerebral O<jats:sub>2<\/jats:sub> consumption was related to changes in the importance of N\u2010methyl\u2010D\u2010aspartate (NMDA) receptors. Young (4 weeks) male control Long Evans (N = 14) and Eker (N = 14) rats (70\u2013100 g) were divided into control and CGS\u201019755 (10 mg\/kg, competitive NMDA antagonist)\u2010treated animals. Cerebral regional blood flow (<jats:sup>14<\/jats:sup>C\u2010iodoantipyrine) and O<jats:sub>2<\/jats:sub> consumption (cryomicrospectrophotometry) were determined in isoflurane\u2010anesthetized rats. NMDA receptor protein levels were determined by Western immunoblotting. We found significantly increased basal O<jats:sub>2<\/jats:sub> consumption in the cortex (6.2 \u00b1 0.6 ml O<jats:sub>2<\/jats:sub>\/min\/100 g Eker vs. 4.7 \u00b1 0.4 Long Evans), hippocampus, cerebellum, and pons. Regional cerebral blood flow was also elevated in Eker rats at baseline, but cerebral O<jats:sub>2<\/jats:sub> extraction was similar. CGS\u201019755 significantly lowered O<jats:sub>2<\/jats:sub> consumption in the cortex (2.8 \u00b1 0.3), hippocampus, and pons of the Long Evans rats but had no effect on cortex (5.8 \u00b1 0.8) or other regions of the Eker rats. Cerebral blood flow followed a similar pattern. NMDA receptor protein levels (NR1 subunit) were similar between groups. In conclusion, Eker rats had significantly elevated cerebral O<jats:sub>2<\/jats:sub> consumption and blood flow, but this was not related to NMDA receptor activation. In fact, the importance of NMDA receptors in the control of basal cerebral O<jats:sub>2<\/jats:sub> consumption was reduced. This might have important implications in the treatment of autism. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.21378","type":"journal-article","created":{"date-parts":[[2007,6,4]],"date-time":"2007-06-04T22:47:18Z","timestamp":1180997238000},"page":"2512-2517","source":"Crossref","is-referenced-by-count":9,"title":["Increased cerebral oxygen consumption in Eker rats and effects of N\u2010methyl\u2010D\u2010aspartate blockade: Implications for autism"],"prefix":"10.1002","volume":"85","author":[{"given":"Harvey R.","family":"Weiss","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qihang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oak 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