{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T12:14:26Z","timestamp":1790943266437,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2007,7,30]],"date-time":"2007-07-30T00:00:00Z","timestamp":1185753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Amyloid \u03b2 (A\u03b2) peptide related to the onset of Alzheimer's disease (AD) damaged neurons and further resulted in dementia. <jats:italic>Monascus<\/jats:italic>\u2010fermented red mold rice (RMR), a traditional Chinese medicine as well as health food, includes monacolins (with the same function as statins) and multifunctional metabolites. In this study, ethanol extract of RMR (RE) was used to evaluate neuroprotection against A\u03b240 neurotoxicity in PC12 cells. Furthermore, the effects of dietary administration of RMR on memory and learning abilities are confirmed in an animal model of AD rats infused with A\u03b240 into the cerebral ventricle. During continuous A\u03b240 infusion for 28 days, the rats of test groups were administered RMR or lovastatin. Memory and learning abilities were evaluated in the water maze and passive avoidance tasks. After sacrifice, cerebral cortex and hippocampus were collected for the examination of AD risk factors. The in vitro results clearly indicate that RE provides stronger neuroprotection in rescuing cell viability as well as repressing inflammatory response and oxidative stress. RMR administration potently reverses the memory deficit in the memory task. A\u03b240 infusion increases acetylcholinesterase activity, reactive oxygen species, and lipid peroxidation and decreases total antioxidant status and superoxide dismutase activity in brain, but these damages were potently reversed by RMR administration, and the protection was more significant than that with lovastatin administration. The protection provided by RMR is able to prevent A\u03b2 fibrils from being formed and deposited in hippocampus and further decrease A\u03b240 accumulation, even though A\u03b240 solution was infused into brain continuously. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.21428","type":"journal-article","created":{"date-parts":[[2007,7,31]],"date-time":"2007-07-31T00:16:35Z","timestamp":1185840995000},"page":"3171-3182","source":"Crossref","is-referenced-by-count":77,"title":["Red mold rice ameliorates impairment of memory and learning ability in intracerebroventricular amyloid \u03b2\u2010infused rat by repressing amyloid \u03b2 accumulation"],"prefix":"10.1002","volume":"85","author":[{"given":"Chun\u2010Lin","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzong\u2010Fu","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyh\u2010Jye","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu\u2010Ming","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,7,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf040199p"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-3623(98)00183-9"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(00)00188-X"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(84)90292-1"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)50881-X"},{"key":"e_1_2_6_7_1","volume-title":"The growth of the surface area of human body","author":"Boyd E","year":"1935"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:NERE.0000042217.90204.8d"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/13506120500535636"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M505268200"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2003.09.004"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.32.852"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(82)90118-X"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200161010-00005"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2005.11.011"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2003.11.005"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2003.10.018"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01569999"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(96)00236-1"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1998.70052179.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.18211"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-1-23"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-005-0137-0"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-006-0404-8"},{"key":"e_1_2_6_25_1","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1093\/jaoac\/89.3.669","article-title":"Synchronous analysis method for detection of citrinin and the lactone and acid forms of monacolin K in red mold rice","volume":"89","author":"Lee CL","year":"2006","journal-title":"JAOAC Int"},{"key":"e_1_2_6_26_1","unstructured":"LeeCL WangJJ PanTM.2006d.Monascusextract repress the toxicity of Alzheimer's risk factor\u2014amyloid \u03b2\u2010protein in PC\u201012 cell model. Proc Ann Meeting Inst Food Technologist 078G\u201001."},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21053"},{"key":"e_1_2_6_28_1","first-page":"300","article-title":"Anti\u2010dementia effects of grape peel extracts experiment study","volume":"35","author":"Long MS","year":"2006","journal-title":"Wei Sheng Yan Jiu"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf000338c"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(84)90007-4"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.174.241"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(79)90738-3"},{"key":"e_1_2_6_33_1","volume-title":"The rat brain in stereotaxic coordinates: the new coronal set","author":"Paxinos G","year":"2005"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(94)11182-I"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(99)00132-4"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.6.1989"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003160"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2004.00113.x"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10295-002-0001-5"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1006\/nlme.1997.3770"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-3620rev"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.18.2283"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-005-0051-5"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.80.9"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.105.098640"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1354.032"}],"container-title":["Journal of Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjnr.21428","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.21428","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T07:31:16Z","timestamp":1700033476000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jnr.21428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7,30]]},"references-count":45,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2007,11]]}},"alternative-id":["10.1002\/jnr.21428"],"URL":"https:\/\/doi.org\/10.1002\/jnr.21428","archive":["Portico"],"relation":{},"ISSN":["0360-4012","1097-4547"],"issn-type":[{"value":"0360-4012","type":"print"},{"value":"1097-4547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,7,30]]}}}