{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T11:58:33Z","timestamp":1774785513160,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,9,26]],"date-time":"2007-09-26T00:00:00Z","timestamp":1190764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2008,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Parkinson's disease (PD) is characterized by loss of nigral dopaminergic (DAergic) neurons and presence of Lewy bodies, whose major component is \u03b1\u2010synuclein. We had previously generated transgenic mice termed <jats:italic>Syn130m<\/jats:italic> that express truncated human \u03b1\u2010synuclein (amino acid residues 1\u2013130) in DAergic neurons. Syn130m mice showed significant loss of DAergic neurons in the substantia nigra pars compacta. Subsequently, the striatal DA level and spontaneous locomotor activity of the mice were decreased significantly. In the present study, we investigated behavioral responses of Syn130m mice to L\u2010DOPA and DA receptor agonists. Administration of L\u2010DOPA dose dependently ameliorated the reduction of spontaneous locomotor activity of Syn130m mice. Similarly, D<jats:sub>2<\/jats:sub> agonists, quinpirole and talipexole, and a D<jats:sub>1<\/jats:sub>\/D<jats:sub>2<\/jats:sub> agonist, pergolide, were effective against the reduction. Syn130m mice also showed significant reduction in exploratory behavior compared with non\u2010Tg littermates when they were placed in a novel environment, but this abnormality was ameliorated by treatment with pergolide. These results strongly suggest that the behavioral abnormalities of Syn130m mice were caused by low striatal DA content. On the other hand, the expression of postsynaptic D<jats:sub>2<\/jats:sub>\u2010like receptors (DRD<jats:sub>2<\/jats:sub>) in the striatum was not increased in Syn130m mice, although the low striatal DA level is known to induce compensatory expression of DRD<jats:sub>2<\/jats:sub>. Because the abnormalities could be rectified by treatment with DA receptor agonists, it is likely that Syn130m mice provide a useful tool to explore therapeutic possibilities for PD as a new animal model of the disease. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.21513","type":"journal-article","created":{"date-parts":[[2007,9,26]],"date-time":"2007-09-26T22:47:01Z","timestamp":1190846821000},"page":"640-646","source":"Crossref","is-referenced-by-count":20,"title":["Dopamine receptor agonists reverse behavioral abnormalities of \u03b1\u2010synuclein transgenic mouse, a new model of Parkinson's disease"],"prefix":"10.1002","volume":"86","author":[{"given":"Masaki","family":"Wakamatsu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shingo","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeo","family":"Funakoshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Yoshimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,9,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.3.887"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)00734-3"},{"key":"e_1_2_6_4_1","first-page":"4947","article-title":"Phase I study of talipexole dihydrochloride (B\u2010HT 920)","volume":"20","author":"Azuma J","year":"1992","journal-title":"Jpn Pharmacol Ther"},{"key":"e_1_2_6_5_1","first-page":"879","article-title":"Aggregation of alpha\u2010synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies","volume":"152","author":"Baba M","year":"1998","journal-title":"Am J Pathol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-17-06853.2001"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0893-133X(94)00129-N"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1443"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(72)90136-7"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.877576"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(98)01418-5"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0077587"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(80)90695-2"},{"key":"e_1_2_6_14_1","first-page":"600","article-title":"Similarities and differences between MPTP\u2010induced parkinsonsim and Parkinson's disease. 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