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Therefore, it mimics conditions of lacunar infarctions, one of the most frequent human stroke pathologies. Doublecortin (DCX)\u2010positive cells were present in the neocortex and corpus callosum at the base of the lesion. The number of DCX\u2010positive cells in the corpus callosum was significantly increased from day 5 to day 14 compared with the control group. In contrast, there were no DCX\u2010positive cells in neocortex of control animals; the DCX\u2010positive cells appeared in the neocortex after lesioning and were maintained until 14 days postlesioning. Some of the DCX\u2010positive cells were also immunoreactive for \u03b2III\u2010tubulin, another marker of immature neurons. They did not stain positively for markers of glia cells. The presence of these DCX\u2010positive cells near the lesion might indicate a migratory pathway for developing neuroblasts from the subventricular zone (SVZ) through the corpus callosum to the lesion. SVZ cells were labeled with a lipophilic molecule, 5\u2010 (and 6\u2010) carboxyfluorescein diacetate succinimidyl ester (CFSE) stereotaxical injections. Although rostral migratory stream and olfactory bulb were intensely labeled, no CFSE\u2010containing cells were found in the cortex beneath the lesion. These results do not support the idea that the DCX\u2010positive cells were originating from neural precursors of the SVZ, but they might be generated from local progenitor cells. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.21546","type":"journal-article","created":{"date-parts":[[2007,10,25]],"date-time":"2007-10-25T21:42:55Z","timestamp":1193348575000},"page":"883-893","source":"Crossref","is-referenced-by-count":14,"title":["Doublecortin\u2010expressing cells in the ischemic penumbra of a small\u2010vessel 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