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We have previously demonstrated that DDR1 mediates collagen\u2010induced nitric oxide production in J774A.1 murine macrophages. Because collagen is one of the main components of extracellular matrix in the central nervous system, we hypothesized that collagen also induces inflammatory activation of brain microglia, and DDR1 may mediate collagen\u2010induced microglial activation. Using BV\u20102 mouse microglial cells and mouse primary microglial cultures, we have demonstrated that (1) collagen induces inflammatory activation of microglia as evidenced by production of nitric oxide, expression of inducible nitric oxide synthase, COX\u20102, CD40, and matrix metalloproteinase\u20139; (2) DDR1 is expressed in microglia and is phosphorylated by collagen treatment; and (3) collagen\u2010induced microglial activation is abrogated by DDR1 blockade but not by integrin neutralization. We have further shown that p38 MAPK, c\u2010Jun N\u2010terminal kinase, and nuclear factor\u2013kappa B are involved in the collagen\u2010DDR1\u2010induced microglial activation. Our results suggest that collagen can induce inflammatory activation of brain microglia and that DDR1 mediates this effect of collagen in an integrin\u2010independent manner. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.21552","type":"journal-article","created":{"date-parts":[[2007,10,29]],"date-time":"2007-10-29T21:13:36Z","timestamp":1193692416000},"page":"1087-1095","source":"Crossref","is-referenced-by-count":35,"title":["Discoidin domain receptor 1 mediates collagen\u2010induced inflammatory activation of microglia in 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