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RAGE has not previously been reported in neonatal rat oligodendrocytes (NRO), but, by using primers specific for rat RAGE, we were able to show expression of messenger RNA (mRNA) for RAGE in NRO, and a 55\u2010kDa protein was detected by Western blotting with antibodies to RAGE. Neonatal rat oligodendrocytes stained strongly for RAGE, suggesting membrane localization of RAGE. Addition of low concentrations of hydrogen peroxide (100 \u03bcM) initiated 55\u2010kDa RAGE shedding from the cell membrane and the appearance of \u201csoluble\u201d 45\u2010kDa RAGE in the culture medium, followed by restoration of RAGE expression to normal levels. Increasing hydrogen peroxide concentration (&gt;200 \u03bcM) resulted in no restoration of RAGE, and the cells underwent apoptosis and necrosis. We further confirmed the observation in a human oligodendroglioma\u2010derived (HOG) cell line. Both the antioxidant N\u2010acetyl\u2010L\u2010cysteine and the broad\u2010spectrum metalloproteases inhibitor TAPI0 were able partially to inhibit shedding of RAGE, suggesting involvement of metalloproteases in cleavage to produce soluble RAGE. The level of 55\u2010kDa RAGE in autopsy brain of patients undergoing neurodegeneration with accompanying inflammation [multiple sclerosis and neuronal ceroid\u2010lipofuscinosis (Batten's disease)] was much lower than that in age\u2010matched controls, suggesting that shedding of RAGE might occur as reactive oxygen species accumulate in brain cells and be part of the process of neurodegeneration. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.21692","type":"journal-article","created":{"date-parts":[[2008,4,26]],"date-time":"2008-04-26T00:46:56Z","timestamp":1209170816000},"page":"2414-2422","source":"Crossref","is-referenced-by-count":47,"title":["Expression of the receptor for advanced glycation end products in oligodendrocytes in response to oxidative 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