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Recent studies have claimed that these neurotrophic factors are important tools for therapeutic intervention in neurodegenerative diseases. So far, little is known about the age\u2010 and disease\u2010modulated time course of cerebral neurotrophins. Therefore, we have studied protein concentrations of BDNF, NGF, and NT\u20103 in different brain areas and sciatic nerve, a neurotrophin\u2010transporting peripheral nerve, in a well\u2010characterized AD model of amyloid precursor protein\u2010overexpressing rodents (APP23 mice) at the ages of 5.0, 10.5, and 20.0 months. In APP23 mice, there was a significant increase of BDNF and NGF in the frontal and occipital cortices (for BDNF also in the striatum) of old 20.0\u2010month\u2010old mice (with respect to median values up to 8.2\u2010fold), which was highly correlated with amyloid concentrations of these brain areas. Median values of NGF and NT\u20103 showed up to a 6.0\u2010fold age\u2010dependent increase in the septum that was not detectable in APP23 mice. Hippocampus, olfactory bulb, and cerebellum (except NT\u20103) did not show substantial age\u2010 or genotype\u2010related regulation of neurotrophins. In the sciatic nerve, BDNF and NGF levels are increased in5\u2010month\u2010old APP23 mice and decrease with age to control levels. In conclusion, APP23 mice show a genotype\u2010dependent increase of cortical BDNF and NGF that is highly correlated with amyloid concentrations and may reflect an amyloid\u2010related glia\u2010derived neurotrophin secretion or an altered axonal transport of these neurotrophic factors. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.21704","type":"journal-article","created":{"date-parts":[[2008,4,25]],"date-time":"2008-04-25T20:47:57Z","timestamp":1209156477000},"page":"2774-2783","source":"Crossref","is-referenced-by-count":28,"title":["Age\u2010dependent time course of cerebral brain\u2010derived neurotrophic factor, nerve growth factor, and neurotrophin\u20103 in APP23 transgenic 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