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Neuropilin\u2010dependent class 3 semaphorin signaling guides axons during neural development, but the significance of this signaling system for regeneration of adult peripheral nerves is not known. To test the hypothesis that neuropilin\u20102 facilitates peripheral\u2010nerve axonal regeneration, we crushed sciatic nerves of adult neuropilin\u20102\u2010deficient and littermate control mice. Axonal regeneration through the crush site and into the distal nerve segment, repression by the regenerating axons of Schwann cell p75 neurotrophin receptor expression, remyelination of the regenerating axons, and recovery of normal gait were all significantly slower in the neuropilin\u20102\u2010deficient mice than in the control mice. Thus, neuropilin\u20102 facilitates peripheral\u2010nerve axonal regeneration. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.21766","type":"journal-article","created":{"date-parts":[[2008,7,9]],"date-time":"2008-07-09T18:37:16Z","timestamp":1215628636000},"page":"3163-3169","source":"Crossref","is-referenced-by-count":26,"title":["Peripheral nerve regeneration is delayed in neuropilin 2\u2013deficient 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