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Evidence for this from animal models is based mainly on studies that used a model of carotid artery ligation with hypoxia in postnatal rats. However, little is known about the role of cytokines in brain injury after whole\u2010body hypoxia at the time of birth. This study used a well\u2010established rat model of global birth hypoxia to assess mRNA and protein expression of three key proinflammatory cytokines, interleukin\u20101\u03b2 (IL\u20101\u03b2), IL\u20106, and tumor necrosis factor\u2010\u03b1, (TNF\u2010\u03b1) in the brain, liver, and kidney of neonates. We observed decreased IL\u20101\u03b2 and TNF\u2010\u03b1 protein, and decreased IL\u20106 mRNA in brains of neonates in the 2 hr after birth hypoxia but increased IL\u20106 and IL\u20101\u03b2 in liver compared with vaginally born controls. Increasing the severity of the insult by increasing the period of anoxic exposure further decreased brain IL\u20101\u03b2, whereas delivering anoxia under hypothermic conditions, known to be neuroprotective, attenuated the decrease in brain IL\u20101\u03b2. These data suggest that decreased brain levels of inflammatory cytokines may modulate central nervous system responses to global birth hypoxia in rats. Our findings of decreased brain cytokine expression after global birth hypoxia contrast with reports of increased brain cytokines after carotid artery ligation with hypoxia in postnatal rats; possible reasons for these differences are discussed. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.21785","type":"journal-article","created":{"date-parts":[[2008,7,14]],"date-time":"2008-07-14T22:11:43Z","timestamp":1216073503000},"page":"3401-3409","source":"Crossref","is-referenced-by-count":14,"title":["Acute brain cytokine responses after global birth hypoxia in the rat"],"prefix":"10.1002","volume":"86","author":[{"given":"Helen","family":"Ashdown","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Joita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giamal 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