{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:52:00Z","timestamp":1790614320753,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,9,24]],"date-time":"2008-09-24T00:00:00Z","timestamp":1222214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2009,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    It has previously been demonstrated that 1,25\u2010dihydroxyvitamin D\n                    <jats:sub>3<\/jats:sub>\n                    [1,25(OH)\n                    <jats:sub>2<\/jats:sub>\n                    D\n                    <jats:sub>3<\/jats:sub>\n                    ] administration, whether in cell cultures or in vivo to rats, increases glial cell line\u2010derived neurotrophic factor (GDNF) expression levels, suggesting that this hormone may have beneficial effects in neurodegenerative disorders. This study was carried out to explore the effects of 1,25(OH)\n                    <jats:sub>2<\/jats:sub>\n                    D\n                    <jats:sub>3<\/jats:sub>\n                    administration in a 6\u2010OHDA\u2010lesioned rat model of Parkinson's disease on GDNF and tyrosine hydroxylase (TH) expression in substantia nigra (SN) and striatum. Two groups of animals received 1,25(OH)\n                    <jats:sub>2<\/jats:sub>\n                    D\n                    <jats:sub>3<\/jats:sub>\n                    intraperitoneally, the first group 7 days before the unilateral injection of 6\u2010OHDA into the medial forebrain bundle (MFB) and the second group 21 days (days 21\u201328) after the unilateral injection of 6\u2010OHDA. Animals of both groups were sacrificed on day 28. In addition, two other groups received a unilateral injection of either saline or 6\u2010OHDA into the MFB. Rats were killed, and the SN and striatum were then removed for GDNF and TH determination. Striatal GDNF protein expression was increased on the ipsilateral with respect to the contralateral side after 6\u2010OHDA injection alone as well as in 1,25(OH)\n                    <jats:sub>2<\/jats:sub>\n                    D\n                    <jats:sub>3<\/jats:sub>\n                    \u2010treated rats before or after 6\u2010OHDA administration. As expected, 6\u2010OHDA injection induced an ipsilateral decrease in TH\u2010immunopositive neuronal cell bodies and axonal terminals in the SN and striatum. However, treatment with 1,25(OH)\n                    <jats:sub>2<\/jats:sub>\n                    D\n                    <jats:sub>3<\/jats:sub>\n                    before and after 6\u2010OHDA injection partially restored TH expression in SN. These data suggest that 1,25(OH)\n                    <jats:sub>2<\/jats:sub>\n                    D\n                    <jats:sub>3<\/jats:sub>\n                    may help to prevent dopaminergic neuron damage. \u00a9 2008 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/jnr.21878","type":"journal-article","created":{"date-parts":[[2008,9,24]],"date-time":"2008-09-24T16:13:23Z","timestamp":1222272803000},"page":"723-732","source":"Crossref","is-referenced-by-count":106,"title":["1,25\u2010Dihydroxyvitamin D\n                    <sub>3<\/sub>\n                    administration to 6\u2010hydroxydopamine\u2010lesioned rats increases glial cell line\u2010derived neurotrophic factor and partially restores tyrosine hydroxylase expression in substantia nigra and striatum"],"prefix":"10.1002","volume":"87","author":[{"given":"Bego\u00f1a","family":"Sanchez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose 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