{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:53:59Z","timestamp":1791122039794,"version":"4.1.0"},"reference-count":100,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2009,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Minocycline is a second\u2010generation tetracycline and a potential neuroprotective intervention following brain injury. However, despite the recognized beneficial effects of minocycline in a multitude of adult disease states, the clinical application of minocycline in neonates is contentious. Tetracyclines, as a class, are not usually administered to neonates, but there is compelling evidence that minocycline reduces brain injury after neonatal hypoxic\u2010ischemic brain injury. This Review focuses on the evidence for minocycline use in neonates by considering aspects of pharmacology, drug regimens, functional outcomes, and mechanisms of action. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.21890","type":"journal-article","created":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T13:52:30Z","timestamp":1222869150000},"page":"599-608","source":"Crossref","is-referenced-by-count":63,"title":["Minocycline: A neuroprotective agent for hypoxic\u2010ischemic brain injury in the neonate?"],"prefix":"10.1002","volume":"87","author":[{"given":"Kathryn M.","family":"Buller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle L.","family":"Carty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna E.","family":"Reinebrant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Wixey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000103741"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.24.14014"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.24.3264"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10242"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"6241","DOI":"10.1523\/JNEUROSCI.18-16-06241.1998","article-title":"Maturation\u2010dependent vulnerability of oligodendrocytes top oxidative stress\u2010induced death caused by glutathione depletion","volume":"18","author":"Back SA","year":"1998","journal-title":"J Neurosci"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000254729.27386.05"},{"key":"e_1_2_9_8_1","first-page":"270","article-title":"Cytokines are associated with cerebral metabolism and outcome in term neonatal encephalopathy","volume":"27","author":"Bartha AI","year":"2005","journal-title":"Dev Neurosci"},{"key":"e_1_2_9_9_1","first-page":"49","article-title":"Antimicrobial spectrum, pharmacology and therapeutic use of antibiotics. Part 1: tetracyclimes","volume":"34","author":"Barza M","year":"1977","journal-title":"Am J Hosp Pharm"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20266"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.30.9.1916"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2006.01.037"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4347(91)80174-B"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199904010-00008"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-197509040-00005"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3181659774"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-4328(94)00108-R"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2005.09.023"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2008.02.005"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/77528"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20727"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.25.7.1411"},{"key":"e_1_2_9_23_1","first-page":"337","article-title":"Liquid chromatographic determination of minocycline in brain\u2010to\u2010plasma distribution studies in rat","volume":"791","author":"Colovic M","year":"2003","journal-title":"J Chromatogr"},{"key":"e_1_2_9_24_1","first-page":"799","article-title":"Acne: treatment with minocycline","volume":"17","author":"Coskey RJ","year":"1976","journal-title":"Cutis"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4886(03)00032-3"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(03)00558-X"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.251341998"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.26.4.515"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2003.12.006"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2005.06.033"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2005.02.016"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20623"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.04918.x"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.11.4.712"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-004-0864-9"},{"key":"e_1_2_9_36_1","first-page":"21","article-title":"Safety and efficacy of a new extended\u2010release formulation of minocycline","volume":"78","author":"Fleischer ABJ","year":"2006","journal-title":"Cutis"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600121"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1991.tb01626.x"},{"key":"e_1_2_9_39_1","first-page":"105","article-title":"A new tetracycline minocycline compared with ampicillin in general practice","volume":"83","author":"Gallagher DJ","year":"1976","journal-title":"N Z Med J"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1159\/000103740"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345870660080401"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.12.5.642"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2003-1017-L"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199610000-00015"},{"key":"e_1_2_9_45_1","volume-title":"Goodman and Gilman's the pharmacological basis of therapeutics","author":"Hardman JG","year":"1996"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/62.5.441"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(99)00678-5"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.25.995"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(03)00743-2"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(00)00287-4"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199601000-00006"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600025"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.2174\/156720107781023938"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.10.1278"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)30039-6"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2005.01.010"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21380"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20335"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000277487.04281.db"},{"key":"e_1_2_9_60_1","volume-title":"Clinical pharmacology","author":"Laurence DR","year":"1987"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.04182.x"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(03)00498-6"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1973145852"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-7-56"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2006.09.008"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200011000-00002"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(94)00177-2"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.10.052"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600700230"},{"key":"e_1_2_9_70_1","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S0090-9556(25)07851-1","article-title":"Metabolism of minocycline in humans","volume":"10","author":"Nelis HJCF","year":"1982","journal-title":"Drug Metab Dispos"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(95)00282-N"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.5.939"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10553"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-200106000-00051"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2006.03.010"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1067\/S0022-3476(03)00531-6"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000072517.01207.87"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5275-03.2004"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05973.x"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4391-06.2007"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000137768.25203.df"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0306239101"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1996.67031014.x"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.12.7527"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-08-02580.2001"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2004.01.010"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000223353.34006.54"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2004.01.011"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2779(1997)3:1<1::AID-MRDD1>3.0.CO;2-W"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200111000-00003"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M313629200"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e318123f757"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2007.06.025"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-05-01763.2002"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-4-7"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.01.144"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000206281.77178.ac"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.26.15769"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.23.13496"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458506070319"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/417074a"}],"container-title":["Journal of Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjnr.21890","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.21890","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T05:10:47Z","timestamp":1738386647000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jnr.21890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":100,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,2,15]]}},"alternative-id":["10.1002\/jnr.21890"],"URL":"https:\/\/doi.org\/10.1002\/jnr.21890","archive":["Portico"],"relation":{},"ISSN":["0360-4012","1097-4547"],"issn-type":[{"value":"0360-4012","type":"print"},{"value":"1097-4547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10]]}}}