{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:36:29Z","timestamp":1788176189690,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2009,1,30]],"date-time":"2009-01-30T00:00:00Z","timestamp":1233273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2009,1,30]],"date-time":"2009-01-30T00:00:00Z","timestamp":1233273600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Nuclear factor\u2010kappa B (NF\u2010\u03baB) comprises a family of inducible transcription factors that serve as important regulators of the host immune and inflammatory responses. The NF\u2010\u03baB signals are activated via the canonical and\/or noncanonical pathways in response to diverse stimuli. The excessive action of NF\u2010\u03baB signal\u2010transduction pathways frequently causes self\u2010injurious phenomena such as allergic diseases, vascular disorders, and ischemia\u2013reperfusion neuronal damage. In the inner ear, the role of NF\u2010\u03baB has not been clarified because the activated NF\u2010\u03baB signals potentially induce both cytoprotective and cytotoxic target genes after ototoxic stimulation. In the present study, we investigated the response of NF\u2010\u03baB in both the canonical and noncanonical pathways to acoustic overstimulation (117 dB\/SPL\/2 hr) and followed the change of inflammatory factors (inducible nitric oxide synthase [iNOS], intracellular adhesion molecule\u20101 [ICAM\u20101], and vascular cell adhesion molecule\u20101 [VCAM\u20101]) in the cochlear lateral wall (CLW) and the rest of cochlea (RoC). By means of immunohistochemistry combined with confocal microscopy and reverse transcriptase\u2013polymerase chain reaction techniques, we found the response of NF\u2010\u03baB family members (NF\u2010\u03baB1, 2, RelA, and RelB) at the transcription level. After the NF\u2010\u03baB signaling, the inflammatory factors were significantly increased in the CLW and the RoC. Additionally, at the protein level, the prominent expression of adhesion molecules (ICAM\u20101 and VCAM\u20101) was observed in the tissue around the capillaries in the stria vascularis. These results show that acoustic overstimulation causes the NF\u2010\u03baB signaling to overexpress the inflammatory factors in the inner ear, and the up\u2010regulation of the adhesion molecules (ICAM\u20101 and VCAM\u20101) and iNOS potentially influence the hemodynamics and the cellular integrity in the stria vascularis. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.22018","type":"journal-article","created":{"date-parts":[[2009,1,30]],"date-time":"2009-01-30T16:58:32Z","timestamp":1233334712000},"page":"1832-1840","source":"Crossref","is-referenced-by-count":68,"title":["The influence of NF\u2010\u03baB signal\u2010transduction pathways on the murine inner ear by acoustic overstimulation"],"prefix":"10.1002","volume":"87","author":[{"given":"Hiroshi","family":"Yamamoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Omelchenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaorui","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred 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