{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T04:22:57Z","timestamp":1775535777239,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2009,4,20]],"date-time":"2009-04-20T00:00:00Z","timestamp":1240185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Epidemiological studies have indicated that excessive alcohol consumption leads to cognitive impairment, but the specific pathological mechanism involved remains unknown. The present study evaluated the association between heavy alcohol intake and the neuropathological hallmark lesions of the three most common neurodegenerative disorders, i.e., Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and vascular cognitive impairment (VCI), in post\u2010mortem human brains. The study cohort was sampled from the subjects who underwent a medicolegal autopsy during a 6\u2010month period in 1999 and it included 54 heavy alcohol consumers and 54 age\u2010 and gender\u2010matched control subjects. Immunohistochemical methodology was used to visualize the aggregation of \u03b2\u2010amyloid, hyperphosphorylated \u03c4, and \u03b1\u2010synuclein and the extent of infarcts. In the present study, no statistically significant influence was observed for alcohol consumption on the extent of neuropathological lesions encountered in the three most common degenerative disorders. Our results indicate that alcohol\u2010related dementia differs from VCI, AD, and DLB; i.e., it has a different etiology and pathogenesis. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.22091","type":"journal-article","created":{"date-parts":[[2009,4,20]],"date-time":"2009-04-20T21:02:34Z","timestamp":1240261354000},"page":"2786-2792","source":"Crossref","is-referenced-by-count":31,"title":["Heavy alcohol consumption and neuropathological lesions: A post\u2010mortem human 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