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The auditory system provides a useful model for analyzing these events, insofar as it is subdivided into well\u2010defined groups of specific neuronal types that are readily related to each other at each stage of development. Previous work in our laboratory suggested that NT3 and its receptor TrkC in the mouse cochlear nucleus (CN) may be involved in directing neuronal migration and initial targeting of inputs from cochlear nerve axons in the embryo. NT3 is hard to detect soon after birth, but TrkC lingers longer. Here we found NT3 and TrkC around P8 and the peak around P30. Prominent in ventral CN, associated with globular bushy cells and stellate cells, they were localized to different subcellular sites. The TrkC immunostain was cytoplasmic, and that of NT3 was axonal and perisomatic. TrkC may be made by CN neurons, whereas NT3 has a cochlear origin. The temporal pattern of their development and the likelihood of activity\u2010dependent release of NT3 from cochlear axons suggest that it may not be critical in early synaptogenesis; it may provide long\u2010term trophic effects, including stabilization of synapses once established. Activity\u2010related regulation could coordinate the supply of NT3 with inner ear activity. This may require interaction with other neurotrophins, such as BDNF. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.22179","type":"journal-article","created":{"date-parts":[[2009,7,18]],"date-time":"2009-07-18T06:28:24Z","timestamp":1247898504000},"page":"86-94","source":"Crossref","is-referenced-by-count":14,"title":["Postnatal development of NT3 and TrkC in mouse ventral cochlear 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