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Based on their ramified appearance, positive immunostaining for the monocytic markers Iba1 and annexin A3, and reactivity to bulbectomy (in adult rats), these cells found within the olfactory nerve fascicles of both mammalian species meet several important criteria for their designation as microglia\/macrophages. These Iba1\u2010\/annexin A3\u2010immunopositive cells may be uniquely positioned to protect against the potential spread of dangerous environmental xenobiotics (such as viruses and toxins) into the brain, where such pathogens may contribute to the development of neurological diseases, such Alzheimer's and Parkinson's diseases. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.22254","type":"journal-article","created":{"date-parts":[[2009,10,14]],"date-time":"2009-10-14T20:17:31Z","timestamp":1255551451000},"page":"858-865","source":"Crossref","is-referenced-by-count":37,"title":["Microglial\/macrophage cells in mammalian olfactory nerve fascicles"],"prefix":"10.1002","volume":"88","author":[{"given":"Laura J.","family":"Smithson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Kawaja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,10,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-996-0018-7"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.10160"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-0102(02)00236-5"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986707780597961"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21327"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092100214"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:NEUR.0000010089.37032.48"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-006-9015-5"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1997"},{"key":"e_1_2_6_11_1","first-page":"133","article-title":"Olfaction in neurodegenerative disorder","volume":"63","author":"Hawkes C","year":"2006","journal-title":"Adv Otorhinolaryngol"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1996.1112"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(98)00040-0"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.5.1208"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20482"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21385"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20581"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109218200"},{"key":"e_1_2_6_19_1","article-title":"A review of technical strategies to isolate olfactory ensheathing cells for intraspinal implantation","author":"Kawaja MD","year":"2008","journal-title":"J Neurotrauma"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20562"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20327"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/34.11.2430010"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20241"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(98)00262-5"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.02213.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02656-1"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01175191"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1179\/016164105X49463a"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949410300601"}],"container-title":["Journal of Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjnr.22254","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.22254","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T04:33:35Z","timestamp":1700541215000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jnr.22254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10,14]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["10.1002\/jnr.22254"],"URL":"https:\/\/doi.org\/10.1002\/jnr.22254","archive":["Portico"],"relation":{},"ISSN":["0360-4012","1097-4547"],"issn-type":[{"value":"0360-4012","type":"print"},{"value":"1097-4547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10,14]]}}}