{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:20:27Z","timestamp":1791102027325,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,10,14]],"date-time":"2009-10-14T00:00:00Z","timestamp":1255478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sex differences in cocaine addiction warrants further research focused on examining the growing population of female cocaine addicts. As demonstrated in both clinical and preclinical research, females are more susceptible to drug relapse with anxiety being a contributing factor. In support of this, a recent clinical study from our laboratory highlights the importance of menstrual cycle phase and anxiety at treatment admission for cocaine addiction on treatment retention. In support of these trends in the clinical population, the purpose of the present study was to design an animal model to directly test the role of circulating hormone levels during cocaine withdrawal. To directly measure the influence of estrogen on anxiety\u2010like behavior during early stages of withdrawal, both ovariectomized and intact female rodent models were employed. The elevated\u2010plus maze and elevated\u2010zero maze were used to assess anxiety\u2010like behavior. Recent evidence in male rodents highlights a potential role for the delta opioid\u2010receptor (DOR) system in the modulation of cocaine withdrawal\u2010induced anxiety. In addition to the evaluation of hormonal effects, a potential anxiolytic specific for DOR was tested for its efficacy in females withdrawn from cocaine. Our results support the use of DOR agonists as a potential anxiolytic in females and highlight the importance of estrogen and other circulating hormones during all phases of cocaine addiction. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.22259","type":"journal-article","created":{"date-parts":[[2009,10,14]],"date-time":"2009-10-14T20:17:35Z","timestamp":1255551455000},"page":"816-824","source":"Crossref","is-referenced-by-count":23,"title":["Cocaine withdrawal\u2010induced anxiety in females: Impact of circulating estrogen and potential use of delta\u2010opioid receptor agonists for treatment"],"prefix":"10.1002","volume":"88","author":[{"given":"Lisa M.","family":"Ambrose\u2010Lanci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.C.","family":"Sterling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth J.","family":"Van Bockstaele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,10,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.02.105"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/10550490902772710"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-004-2129-7"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130051028"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2007.07.003"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-002-1030-5"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"R904","DOI":"10.1152\/ajpregu.2001.280.3.R904","article-title":"A comparison of ovariectomy models for estrogen studies","volume":"280","author":"Davidge ST","year":"2001","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(00)88973-7"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(97)90004-6"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(96)00394-2"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(95)02171-X"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/76061"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(00)00392-0"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.75.1.95"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2011738"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/1056-8719(93)90063-K"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(91)90039-Q"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1124\/mi.6.3.7"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.158.4.587"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-008-1089-8"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/383535a0"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.3109\/00952998609083739"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(95)00386-X"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-002-1183-2"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300389"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(01)00593-5"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(02)01041-9"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4530(96)00015-7"},{"key":"e_1_2_7_30_1","first-page":"633","volume-title":"Goodman & Gilman's The Pharmacological Basis of Therapeutics","author":"O'Brian C","year":"2001"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2006.02.002"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(85)90031-7"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706686"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2007.10.007"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2007.04.005"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(99)01399-5"},{"key":"e_1_2_7_37_1","unstructured":"SAMHSA.2006.National Survey of Substance Abuse Treatment Services."},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02244871"},{"key":"e_1_2_7_39_1","first-page":"1","article-title":"Dopamine\u2010dependent behavioural stimulation by non\u2010peptide delta opioids BW373U86 and SNC 80: 1. 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