{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:08:00Z","timestamp":1791180480584,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2010,1,13]],"date-time":"2010-01-13T00:00:00Z","timestamp":1263340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Genetic mutations associated with \u03b1\u2010synuclein (\u03b1\u2010Syn) are implicated in the pathogenesis of Parkinson's disease (PD). PD is primarily a movement disorder, but patients are known to experience anxiety and other mood disorders. In this study, we examined the effect of the hA53T mutation during development by analyzing the protein expression of norepinephrine (NET), serotonin (SERT), and dopamine (DAT) transporters in addition to assessing locomotor and anxiety\u2010like behavior. We observed significant decreases in DAT expression at 8 months in transgenic animals compared with normal and younger mice. We used the elevated plus maze, open\u2010field test, and rotarod apparatus to evaluate wild\u2010type and hA53T hemizygous mice at 2, 8, and 12 months of age. Our results showed that 12\u2010month\u2010old transgenic mice spend more time in the open arms and display a greater number of open entries of the elevated plus maze compared with wild\u2010type controls and younger mice. Open\u2010field test results showed that 12\u2010month\u2010old mice travel a greater distance overall and travel more in the inner zone than either wild\u2010type or younger mice. Rotarod testing showed that 8\u2010 and 12\u2010month\u2010old transgenic mice perform better than either wild\u2010type controls or younger mice. Overall, 8\u201312\u2010month\u2010old transgenic mice showed a trend toward reduced anxiety\u2010like behavior and increased hyperactivity. These results indicate a possible role of the A53T \u03b1\u2010Syn mutation in anxiety\u2010like and hyperactive behaviors in a PD mouse model, suggesting that these behaviors might be comorbid with this disease. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jnr.22331","type":"journal-article","created":{"date-parts":[[2010,1,13]],"date-time":"2010-01-13T16:43:45Z","timestamp":1263401025000},"page":"1777-1783","source":"Crossref","is-referenced-by-count":113,"title":["Mice expressing the A53T mutant form of human alpha\u2010synuclein exhibit hyperactivity and reduced anxiety\u2010like behavior"],"prefix":"10.1002","volume":"88","author":[{"given":"Dianca 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